trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane
structure -
-
CAS No:
66701-25-5
-
Formula:
C15H27N5O5
-
Chemical Name:
trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
Synonyms:
2-Oxiranecarboxylic acid,3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-,(2S,3S)-;Oxiranecarboxylic acid,3-[[[1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-,[2S-[2α,3β(R*)]]-;Oxiranecarboxylic acid,3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-,(2S,3S)-;(2S,3S)-3-[[[(1S)-1-[[[4-[(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid;Proteinase inhibitor E 64;E 64 (proteinase inhibitor);E 64;trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane
- Categories:
-
CAS No:
Description
E-64 is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
E64 is an epoxy monocarboxylic acid, a dicarboxylic acid monoamide, a member of guanidines and a L-leucine derivative. It has a role as a protease inhibitor, an antimalarial and an antiparasitic agent.
trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane Basic Attributes
357.41
357.41
R76F7856MV
29252900
Characteristics
169.93000
0.72150
white solid
1.4±0.1 g/cm3
182ºC
1.618
soluble in DMSO (25mg/ml), or water (20mg/ml)H2O: 20 mg/mL, clear, colorless
2-8°C
Safety Information
Ⅲ
2811
3
6.1
22-24/25
RR0390000
P260-P264-P270-P308 + P311-P501
H371
|Warning|H371 (100%): May cause damage to organs [Warning Specific target organ toxicity, single exposure]|P260, P264, P270, P309+P311, P405, and P501|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory.
Drug Information
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)|Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES. (See all compounds classified as Cysteine Proteinase Inhibitors.)
E 64
trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane Use and Manufacturing
E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but retains specificity
Computed Properties
Molecular Weight:357.41
XLogP3:-0.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:357.20121898
Monoisotopic Mass:357.20121898
Topological Polar Surface Area:172
Heavy Atom Count:25
Complexity:518
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamine
Learn More Other Chemicals
-
L-Cysteine
52-90-4
-
1-chloro-6-Methyl-5-nitroisoquinoline
943606-84-6
-
2-chloro-N-(2-oxothiolan-3-yl)acetamide
84611-22-3
-
N-[(Phenylmethoxy)carbonyl]-L-phenylalanylglycine Formula
13122-99-1
-
(αR)-α-[(Methoxycarbonyl)amino]benzeneacetic acid Formula
50890-96-5
-
3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide Formula
461000-66-8
-
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione Structure
2420-17-9
-
γ-Aminobenzenepropanol Structure
14593-04-5
-
What is tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
170491-63-1
-
What is (R)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
774178-39-1
trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane
SDSRequest for Quotation