 Home > Encyclopedia > 1-METHYL-D-TRYPTOPHAN

1-METHYL-D-TRYPTOPHAN

1-METHYL-D-TRYPTOPHAN structure

CAS No:
110117-83-4
Formula:
C12H14N2O2
Chemical Name:
1-METHYL-D-TRYPTOPHAN
Synonyms:
1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;1-METHYL-D-TRYPTOPHAN 95%;(R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid;IndoxiMod;Indoximod (NLG-8189）;NLG-8189;1-Me-D-Trp
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

Indoximod (D-1MT, NLG8189) is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki of 19 μM.

Indoximod has been used in trials studying the treatment of Glioma, Melanoma, Ependymoma, Gliosarcoma, and Lung Cancer, among others.|Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.

1-METHYL-D-TRYPTOPHAN Basic Attributes

Molecular Weight：

218.25

Exact Mass：

218.105530

UNII：

TX5CYN1KMZ

NSC Number：

721782

NCI Thesaurus Code：

C71535

HScode：

2933990090

Characteristics

PSA：

68.2

XLogP3：

-1.3

Density：

1.28

Melting Point：

242-245 °C(lit.)

Boiling Point：

429.3±35.0 °C(Predicted)

Flash Point：

213.4±25.9 °C

Refractive Index：

1.625

Specific rotation：

12.4o (C = 2 IN ACETIC ACID)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

1-methyl-DL-Trp

1-METHYL-D-TRYPTOPHAN Use and Manufacturing

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

Computed Properties

Molecular Weight:218.25
XLogP3:-1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:218.105527694
Monoisotopic Mass:218.105527694
Topological Polar Surface Area:68.2
Heavy Atom Count:16
Complexity:270
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 1-METHYL-D-TRYPTOPHAN

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

1-Methyl-D-tryptophan

CAS No.: 110117-83-4

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

1-Methyl-D-tryptophan 99% high quality see COA KANBEI

CAS No.: 110117-83-4

Grade: Industrial Grade

Content: 99%

Inquiry

Learn More Other Chemicals

L-Cysteine

52-90-4
1-chloro-6-Methyl-5-nitroisoquinoline

943606-84-6
2-chloro-N-(2-oxothiolan-3-yl)acetamide

84611-22-3
N-[(Phenylmethoxy)carbonyl]-L-phenylalanylglycine Formula

13122-99-1
(αR)-α-[(Methoxycarbonyl)amino]benzeneacetic acid Formula

50890-96-5
3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide Formula

461000-66-8
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione Structure

2420-17-9
γ-Aminobenzenepropanol Structure

14593-04-5
What is tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

170491-63-1
What is (R)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID

774178-39-1

Hot Searches: gibberellic acid; acetonide; 40000/20; oxalic acid formula; no2 compound name; nf3 compound name

Guide of 1-METHYL-D-TRYPTOPHAN

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

1-METHYL-D-TRYPTOPHAN

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.