α-tert-Butoxycarbonyl-L-lysine
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α-tert-Butoxycarbonyl-L-lysine
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CAS No:
13734-28-6
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Formula:
C11H22N2O4
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Chemical Name:
α-tert-Butoxycarbonyl-L-lysine
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Synonyms:
L-Lysine,N2-[(1,1-dimethylethoxy)carbonyl]-;Lysine,N2-carboxy-,N2-tert-butyl ester,L-;N2-[(1,1-Dimethylethoxy)carbonyl]-L-lysine;N2-tert-Butoxycarbonyl-L-lysine;BOC-Lys-OH;α-N-tert-Butoxycarbonyl-L-lysine;α-tert-Butoxycarbonyl-L-lysine;Nα-BOC-L-lysine;NSC 343721;α-N-Boc-lysine;N-α-(tert-Butoxycarbonyl)-L-lysine;(S)-6-Amino-2-(tert-butoxycarbonylamino)hexanoic acid;N-tert-Butoxycarbonyllysine;Nα-Boc-L-lysine;BOC-L-Lys-OH;(2S)-6-Amino-2-[[(tert-butoxy)carbonyl]amino]hexanoic acid;(2S)-6-Azaniumyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate;117457-87-1
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CAS No:
Characteristics
102
-1.6
White Powder
1.1313 (rough estimate)
195-196 °C
389.3°C (rough estimate)
202.0±27.3 °C
21.5 ° (C=2, MeOH)
Soluble in water. Slightly soluble in methanol.
2-8°C
5.65E-08mmHg at 25°C
22 º (c=2, CH3OH)
Safety Information
IRRITANT
NONH for all modes of transport
3
20/21/22-36/37/38
24/25-36-26
Xn
Stable at room temperature in closed containers under normal storage and handling conditions.
α-tert-Butoxycarbonyl-L-lysine Use and Manufacturing
The L-lysine 10mmol join flask, adding 15 ml, acetone 15 ml, stirring, add 2.08 ml of Et3N, controlling the temperature in the 25 °C under stirring di-tert-butyl dicarbonate to 4.27 ml, and to continue stirring 4.5h, decompression evaporate acetone, the water layer is extracted with ethyl ether 3 times, each 10 ml, with dilute HC1 the aqueous layer to adjust pH value to 2-3 rear, ethyl acetate extraction 3 times, each 15 ml, combined with the organic layer, saturated salt for washing 2 times, each 10 ml, anhydrous Na
N-Boc-L-lysine is a protected analogue of a major amino acid participating in the binding of AcH to proteins. N-Boc-L-lysine as well as other t-butoxycarbonyl (Boc) amino acids can be converted to their respective amino acids via cleavage of the urethane bond.
Computed Properties
Molecular Weight:246.30
XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:246.15795719
Monoisotopic Mass:246.15795719
Topological Polar Surface Area:102
Heavy Atom Count:17
Complexity:261
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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