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α-tert-Butoxycarbonyl-L-lysine

α-tert-Butoxycarbonyl-L-lysine structure

α-tert-Butoxycarbonyl-L-lysine 

structure
  • CAS No:

    13734-28-6

  • Formula:

    C11H22N2O4

  • Chemical Name:

    α-tert-Butoxycarbonyl-L-lysine

  • Synonyms:

    L-Lysine,N2-[(1,1-dimethylethoxy)carbonyl]-;Lysine,N2-carboxy-,N2-tert-butyl ester,L-;N2-[(1,1-Dimethylethoxy)carbonyl]-L-lysine;N2-tert-Butoxycarbonyl-L-lysine;BOC-Lys-OH;α-N-tert-Butoxycarbonyl-L-lysine;α-tert-Butoxycarbonyl-L-lysine;Nα-BOC-L-lysine;NSC 343721;α-N-Boc-lysine;N-α-(tert-Butoxycarbonyl)-L-lysine;(S)-6-Amino-2-(tert-butoxycarbonylamino)hexanoic acid;N-tert-Butoxycarbonyllysine;Nα-Boc-L-lysine;BOC-L-Lys-OH;(2S)-6-Amino-2-[[(tert-butoxy)carbonyl]amino]hexanoic acid;(2S)-6-Azaniumyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate;117457-87-1

  • Categories:

    Biochemical Engineering  >  Amino Acids and Derivatives

Description

white to off-white powder

α-tert-Butoxycarbonyl-L-lysine Basic Attributes

246.3

246.30

4252546

237-303-4

343721

2924 19 00

Characteristics

102

-1.6

White Powder

1.1313 (rough estimate)

195-196 °C

389.3°C (rough estimate)

202.0±27.3 °C

21.5 ° (C=2, MeOH)

Soluble in water. Slightly soluble in methanol.

2-8°C

5.65E-08mmHg at 25°C

22 º (c=2, CH3OH)

Safety Information

IRRITANT

NONH for all modes of transport

3

20/21/22-36/37/38

24/25-36-26

Xn

Stable at room temperature in closed containers under normal storage and handling conditions.

α-tert-Butoxycarbonyl-L-lysine Use and Manufacturing

Methods of Manufacturing

The L-lysine 10mmol join flask, adding 15 ml, acetone 15 ml, stirring, add 2.08 ml of Et3N, controlling the temperature in the 25 °C under stirring di-tert-butyl dicarbonate to 4.27 ml, and to continue stirring 4.5h, decompression evaporate acetone, the water layer is extracted with ethyl ether 3 times, each 10 ml, with dilute HC1 the aqueous layer to adjust pH value to 2-3 rear, ethyl acetate extraction 3 times, each 15 ml, combined with the organic layer, saturated salt for washing 2 times, each 10 ml, anhydrous Na

Uses

N-Boc-L-lysine is a protected analogue of a major amino acid participating in the binding of AcH to proteins. N-Boc-L-lysine as well as other t-butoxycarbonyl (Boc) amino acids can be converted to their respective amino acids via cleavage of the urethane bond.

Computed Properties

Molecular Weight:246.30
XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:246.15795719
Monoisotopic Mass:246.15795719
Topological Polar Surface Area:102
Heavy Atom Count:17
Complexity:261
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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