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AG 1478 HYDROCHLORIDE

AG 1478 HYDROCHLORIDE structure

CAS No:
153436-53-4
Formula:
C16H14ClN3O2
Chemical Name:
AG 1478 HYDROCHLORIDE
Synonyms:
N-(3-CHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINANINE HYDROCHLORIDE;4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HCL;4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE;AG-1478;AG 1478 HYDROCHLORIDE;Tyrphostin AG 1478, free base >99%;NSC 693255;(3-Chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine
Categories:
Biochemical Engineering > Inhibitors

Description

AG-1478 is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM.

Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist and an antineoplastic agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.|Tyrphostin AG 1478 is a member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor. (NCI)

AG 1478 HYDROCHLORIDE Basic Attributes

Molecular Weight：

315.75

Exact Mass：

315.75

UNII：

SUH0SEZ9HY

NSC Number：

693255

DSSTox ID：

DTXSID0051447|DTXSID4057891

NCI Thesaurus Code：

C1715

Color/Form：

Light orange to Yellow to Green

HScode：

29339900

Characteristics

λmax：

332nm(lit.)

PSA：

56.3

XLogP3：

Density：

1.337

Melting Point：

247 °C(dec.)

Boiling Point：

458.5±45.0 °C(Predicted)

Flash Point：

231.1±28.7 °C

Refractive Index：

1.668

Storage Conditions：

Desiccate at -20°C

PKA：

5.54±0.30(Predicted)

Critical Temperature & Pressure：

Keep in dark place,Inert atmosphere,2-8°C

Safety Information

RTECS Number：

VA0953000

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

4-(3-chloroanilino)-6,7-dimethoxyquinazoline

AG 1478 HYDROCHLORIDE Use and Manufacturing

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.

AG 1478 Hydrochloride is an epidermal growth factor receptor tyrosine kinase inhibior (EGFR inhibtor).

Computed Properties

Molecular Weight:315.75
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:315.0774544
Monoisotopic Mass:315.0774544
Topological Polar Surface Area:56.3
Heavy Atom Count:22
Complexity:360
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes