N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
-
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
structure -
-
CAS No:
153436-53-4
-
Formula:
C16H14ClN3O2
-
Chemical Name:
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
-
Synonyms:
4-Quinazolinamine,N-(3-chlorophenyl)-6,7-dimethoxy-;N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine;AG 1478;Tyrphostin AG 1478;NSC 693255;(3-Chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine;BRD-K68336408;175178-82-2
- Categories:
-
CAS No:
Description
AG-1478 is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM.
Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist and an antineoplastic agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.|Tyrphostin AG 1478 is a member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor. (NCI)
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine Basic Attributes
352.22
315.75
SUH0SEZ9HY
693255
DTXSID0051447|DTXSID4057891
C1715
29339900
Safety Information
VA0953000
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
4-(3-chloroanilino)-6,7-dimethoxyquinazoline
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine Use and Manufacturing
A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.
Computed Properties
Molecular Weight:315.75
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:315.0774544
Monoisotopic Mass:315.0774544
Topological Polar Surface Area:56.3
Heavy Atom Count:22
Complexity:360
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Latest News on N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
- BMS Over $900 Million to Help Develop Potential 'Best-in-class' SHP2 Inhibitors
- AbbVie's blockbuster product for atopic dermatitis, Upadacitinib, has been approved for marketing in the EU and Japan
- Designing peptide inhibitors for possible COVID-19 treatments
- Chinese scientists discover the inhibitors of SARS-CoV-2
Learn More Other Chemicals
-
Dabrafenib
1195765-45-7
-
BOC-VAL-VAL-OH
69209-73-0
-
BMS 303141
943962-47-8
-
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanamide Formula
60117-17-1
-
(2S)-2-acetamido-6-amino-N-[(2S)-2-amino-3-methylbutanoyl]-N-propylhexanamide Formula
57899-96-4
-
1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea Formula
26130-02-9
-
L-Tyrosyl-L-phenylalanine Structure
17355-11-2
-
C-REACTIVE PROTEIN FRAGMENT 77-82 Structure
130349-01-8
-
What is Sildenafil
139755-83-2
-
What is Dacomitinib
1110813-31-4
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
SDSRequest for Quotation