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Aclidinium bromide

Aclidinium bromide structure

CAS No:
320345-99-1
Formula:
C26H30NO4S2.Br
Chemical Name:
Aclidinium bromide
Synonyms:
1-Azoniabicyclo[2.2.2]octane,3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-,bromide (1:1),(3R)-;1-Azoniabicyclo[2.2.2]octane,3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-,bromide,(3R)-;Aclidinium bromide;LAS 34273;LAS-W 330;(3R)-(2-Hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide;Genuair;Eklira Genuair;Bretaris Genuair
Categories:
Biochemical Engineering > Inhibitors

Description

Aclidinium Bromide(LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (COPD). IC50 value:Target: M3 receptorPreclinically, aclidinium showed potent antagonism of human muscarinic receptors, with a long residence time at M3 receptors and a shorter residence time at M2 receptors, indicating the potential to provide sustained bronchodilation. Aclidinium is rapidly hydrolysed in human plasma, unlike other

Aclidinium bromide is a quaternary ammonium salt that is the bromide salt of aclidinium. A muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD). It has a role as a muscarinic antagonist and a bronchodilator agent. It is a quaternary ammonium salt and an organic bromide salt. It contains an aclidinium.|Aclidinium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

Aclidinium bromide Basic Attributes

Molecular Weight：

564.56

Exact Mass：

563.079956

EC Number：

1592732-453-0

UNII：

UQW7UF9N91

DSSTox ID：

DTXSID30185854

ATC Code：

R03BB|R03AL05|R03AL|R - Respiratory system

Characteristics

PSA：

112

XLogP3：

1.62960

Melting Point：

230 °C @ Solvent: Acetonitrile

Safety Information

GHS Classification：

|Danger|H331 (66.67%): Toxic if inhaled [Danger Acute toxicity, inhalation]|P201, P202, P261, P271, P281, P304+P340, P308+P313, P311, P321, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Hepatotoxicity：

Like other anticholinergic agents, aclidinium has not been linked to episodes of liver enzyme elevations or clinically apparent liver injury. A major reason for its safety may relate to the low systemic absorption and exposure associated with anticholinergic agents administered by inhaler.

Drug Information

Drug Indication：

Eklira Genuair is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).|Bretaris Genuair is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).|Brimica Genuair is indicated as a maintenance bronchodilator treatment for airflow obstruction and relief of symptoms in adult patients with chronic obstructive pulmonary disease (COPD).|Duaklir Genuair is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).

LiverTox Summary：

Aclidinium is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

Drug Classes：

Anticholinergic Agents

MeSH Entry Terms：

(3R)-3-((hydroxy(di-2-thienyl)acetyl)oxy)-1-(3-phenoxypropyl)-1-azoniabicyclo(2.2.2)octane bromide

Aclidinium bromide Use and Manufacturing

Uses

Aclidinium Bromide is a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease.

Use Classification：

Human drugs -> Eklira Genuair -> EMA Drug Category|Drugs for obstructive airway diseases -> Human pharmacotherapeutic group|Human drugs -> Bretaris Genuair -> EMA Drug Category|Human drugs -> Brimica Genuair -> EMA Drug Category|Human drugs -> Duaklir Genuair -> EMA Drug Category|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:564.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:563.07996
Monoisotopic Mass:563.07996
Topological Polar Surface Area:112
Heavy Atom Count:34
Complexity:647
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Aclidinium bromide

CAS No.: 320345-99-1

Content: 99.00%

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