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Naloxone hydrochloride dihydrate

Naloxone hydrochloride dihydrate structure

CAS No:
51481-60-8
Formula:
C19H21NO4.ClH.2H2O
Chemical Name:
Naloxone hydrochloride dihydrate
Synonyms:
Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-,hydrochloride,dihydrate,(5α)-;Naloxone hydrochloride dihydrate;Nyxoid
Categories:
Biochemical Engineering > Inhibitors

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Description

White or almost white, hygroscopic, crystalline powder.

Naloxone hydrochloride dihydrate Basic Attributes

Molecular Weight：

399.87

Exact Mass：

399.144867

EC Number：

206-611-0

UNII：

5Q187997EE

DSSTox ID：

DTXSID90199452

ATC Code：

V03AB15|N07BC51

Characteristics

PSA：

XLogP3：

1.91270

Appearance：

white to off-white powder

Melting Point：

182 °C(dec.)(lit.)

Flash Point：

288.4ºC

Water Solubility：

ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

22-24/25-26-36/37/39-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H302 (14.68%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 109 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Nyxoid is intended for immediate administration as emergency therapy for known or suspected opioid overdose as manifested by respiratory and/or central nervous system depression in both non-medical and healthcare settings.Nyxoid is indicated in adults and adolescents aged 14 years and over.Nyxoid is not a substitute for emergency medical care.|Substitution treatment for opioid drug dependence, within a framework of medical, social and psychological treatment.The intention of the naloxone component is to deter intravenous misuse. Treatment is intended for use in adults and adolescents over 15 years of age who have agreed to be treated for addiction.

Naloxone hydrochloride dihydrate Use and Manufacturing

Uses

Antagonist (to narcotics).

Use Classification：

Human drugs -> Nyxoid -> EMA Drug Category|All other therapeutic products -> Human pharmacotherapeutic group|Human drugs -> Zubsolv -> EMA Drug Category|Other nervous system drugs -> Human pharmacotherapeutic group|Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:399.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:399.1448652
Monoisotopic Mass:399.1448652
Topological Polar Surface Area:72
Heavy Atom Count:27
Complexity:594
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes

Drug Function and Efficacy

1. Completely or partially correct the central inhibitory effects of opioids, such as respiratory depression, sedation and hypotension. 2. It has a wake-promoting effect on animals with acute ethanol intoxication. 3. It is a pure opioid receptor antagonist and does not have the excitatory or morphine-like effects of other opioid receptor antagonists; it does not cause respiratory depression, psychotomimetic reactions or miotic reactions. 4. No drug tolerance, nor physiological or psychological dependence, has been observed. 5. It antagonizes the effects of opioids by competing for the same receptor sites.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Naloxone Hydrochloride Injection
Ingredients	The main component of this product and its chemical name are: 17-allyl-4,5a-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate. Its structural formula is: Molecular formula: C19H21NO4HCl2H2O, molecular weight: 399.87.
Indication	1. The low binding rate and slow dissociation rate of buprenorphine to opioid receptors determine its long duration of action. Therefore, a large dose of naloxone should be used to antagonize the effects of buprenorphine. The antagonism of buprenorphine needs to be gradually enhanced to reverse the effect and shorten the duration of respiratory depression. 2. Methynilbarbital can block the acute withdrawal symptoms induced by naloxone in opioid addicts. 3. This product should not be mixed with preparations containing sodium bisulfate, sodium bisulfite, long-chain polymer anions or any alkaline. Before adding drugs or chemical reagents to the solution of this product, its effect on the chemical and physical stability of the solution should be determined first.
Specifications	1ml:0.4mg
Manufacturer	Shanxi PUDE Pharmaceutical Co., Ltd.

Naloxone Hydrochloride Injection
Ingredients	The main component of this product and its chemical name are: 17-allyl-4,5a-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate. Its structural formula is: Molecular formula: C19H21NO4HCl2H2O, molecular weight: 399.87.
Indication	1. The low binding rate and slow dissociation rate of buprenorphine to opioid receptors determine its long duration of action. Therefore, a large dose of naloxone should be used to antagonize the effects of buprenorphine. The antagonism of buprenorphine needs to be gradually enhanced to reverse the effect and shorten the duration of respiratory depression. 2. Methynilbarbital can block the acute withdrawal symptoms induced by naloxone in opioid addicts. 3. This product should not be mixed with preparations containing sodium bisulfate, sodium bisulfite, long-chain polymer anions or any alkaline. Before adding drugs or chemical reagents to the solution of this product, its effect on the chemical and physical stability of the solution should be determined first.
Specifications	1ml:1mg
Manufacturer	Beijing Wellso Pharmaceutical Co., Ltd.

Naloxone Hydrochloride Injection
Ingredients	The main component of this product and its chemical name are: 17-allyl-4,5a-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate. Its structural formula is: Molecular formula: C19H21NO4HCl2H2O, molecular weight: 399.87.
Indication	1. The low binding rate and slow dissociation rate of buprenorphine to opioid receptors determine its long duration of action. Therefore, a large dose of naloxone should be used to antagonize the effects of buprenorphine. The antagonism of buprenorphine needs to be gradually enhanced to reverse the effect and shorten the duration of respiratory depression. 2. Methynilbarbital can block the acute withdrawal symptoms induced by naloxone in opioid addicts. 3. This product should not be mixed with preparations containing sodium bisulfate, sodium bisulfite, long-chain polymer anions or any alkaline. Before adding drugs or chemical reagents to the solution of this product, its effect on the chemical and physical stability of the solution should be determined first.
Specifications	2ml:2mg
Manufacturer	Suzhou Pharmaceutical Factory

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Registered Holders

NORAMCO LLC

United States
Active
SpecGx LLC

United States
Active
Sun Pharmaceutical Industries Ltd

United States
Active

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Naloxone hydrochloride dihydrate 51481-60-8

CAS No.: 51481-60-8

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Naloxone HCl

CAS No.: 51481-60-8

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Guide of Naloxone hydrochloride dihydrate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

Naloxone hydrochloride dihydrate

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