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Mosapride citrate

Mosapride citrate structure

CAS No:
112885-42-4
Formula:
C21H25ClFN3O3.C6H8O7
Chemical Name:
Mosapride citrate
Synonyms:
Benzamide,4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-,2-hydroxy-1,2,3-propanetricarboxylate (1:1);AS 4370;Mosapride citrate;Gasmotin;Mosid MT;1229354-90-8
Categories:
Biochemical Engineering > Inhibitors

Description

Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.Target: 5HT4 Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. The major active metabolite of mosapride, known as M1, additionally acts as a 5HT3 antagonist, which accelerates gastric emptying throughout the whole of the gastrointestinal tract in humans, and is used for the treatment of gastritis, gastro-oesophageal reflux disease, functional dyspepsia and irritable bowel syndro

Mosapride citrate Basic Attributes

Molecular Weight：

650.05

Exact Mass：

613.183838

EC Number：

1806241-263-5

DSSTox ID：

DTXSID7046207

Characteristics

PSA：

209

XLogP3：

2.62370

Appearance：

white powder

Melting Point：

143-145°

Boiling Point：

549.2ºC at 760mmHg

Flash Point：

286ºC

Storage Conditions：

Desiccate at RT

Vapor Pressure：

4.11E-12mmHg at 25°C

Toxicity：

LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera)

Safety Information

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

GHS Classification：

|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)|Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)

MeSH Entry Terms：

4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide

Mosapride citrate Use and Manufacturing

A selective SR-4 activator and a SR-3 inhibitor

Computed Properties

Molecular Weight:614.0
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:12
Exact Mass:613.1838501
Monoisotopic Mass:613.1838501
Topological Polar Surface Area:209
Heavy Atom Count:42
Complexity:749
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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CAS No.: 112885-42-4

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Mosapride citrate

CAS No.: 112885-42-4

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