1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
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CAS No:
79183-19-0
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Formula:
C15H9Cl2NO2
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Chemical Name:
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
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Synonyms:
APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;Apoptosis Activator 2, >=98%
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CAS No:
Description
Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.IC50 value: 4-9 uM(Leukemia origin cells)[1]Target: Apoptosis activatorin vitro: Apoptosis Activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Apoptosis Activator 2 exerted a cytostatic effect on the majority of cell lines tested, inhibiting cell growth by 50–100% at 10 μM in 40 of 48 cell lines tested. Apoptosis Ac
1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Basic Attributes
306.14
305.001038
RSY8DE8DGH
DTXSID30365533
29145090
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Use and Manufacturing
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
Computed Properties
Molecular Weight:306.1
XLogP3:3.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:305.0010339
Monoisotopic Mass:305.0010339
Topological Polar Surface Area:37.4
Heavy Atom Count:20
Complexity:415
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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What is 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(2,6-DICHLOROBENZYL)OXIME]
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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
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