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IKK 16

IKK 16 structure

CAS No:
873225-46-8
Formula:
C28H29N5OS
Chemical Name:
IKK 16
Synonyms:
IKK Inhibitor;[4-[(4-Benzo[b]thien-2-yl-2-pyriMidinyl)aMino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-Methanone;1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine;IKK Inhibitor VII;Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-;1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine IKK-16 (IKK Inhibitor VII)
Categories:
Biochemical Engineering > Inhibitors

Description

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.

IKK 16 Basic Attributes

Molecular Weight：

483.62776

Exact Mass：

483.209290

Characteristics

PSA：

89.6

XLogP3：

5.67

Density：

1.3±0.1 g/cm3

Boiling Point：

721.6±70.0 °C at 760 mmHg

Flash Point：

390.2±35.7 °C

Refractive Index：

1.700

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

IKK 16 Use and Manufacturing

[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders.

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IKK-16(IKK Inhibitor VII)

CAS No.: 873225-46-8

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