Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
-
![Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2) structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/d0009b6b1b5644b68e835ed5399bf420.png "Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)")
Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
structure -
-
CAS No:
101477-54-7
-
Formula:
C27H30F2N2O3.2ClH
-
Chemical Name:
Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
-
Synonyms:
Piperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-,hydrochloride (1:2);Piperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-,dihydrochloride;KB 2796;Lomerizine dihydrochloride;Lomerizine hydrochloride
- Categories:
-
CAS No:
Description
Colourless Crystalline SolidLomerizine hydrochloride was introduced as Teranas and Migsis in Japan for the treatment of migraine. It is the first in its class of dual sodium and calcium channel blockers to be marketed for this indication. It can be synthetically obtained by reductive amination of 2,3,4-trimethoxybenzaldehyde with the appropiate benzhydryl piperazine. In dogs, Lomerizine exerts a potent, selective and long-lasting vasodilation of cerebral arteries related to a combination
Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2) Basic Attributes
541.46
540.175781
3W473D5LIY
DTXSID1046427
29335990
Characteristics
34.2
6.37760
white to tan
214-218 °C (decomp)
527.3ºC at760mmHg
272.7ºC
DMSO: ≥30mg/mL
-20°C Freezer
LD50 orally in mice: 300 mg/kg (Ohtaka)
Safety Information
UN 3077 9 / PGIII
3
22-50
61
TK9189000
Xn,N
P273-P501
H302-H410
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)
1-(bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2) Use and Manufacturing
A diphenylpiperazine calcium channel blocker. A selective cerebral vasodilator. Antimigraine.
Computed Properties
Molecular Weight:541.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:540.1758046
Monoisotopic Mass:540.1758046
Topological Polar Surface Area:34.2
Heavy Atom Count:36
Complexity:568
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Unspecified
Registered Holders
-
SPH Qingdao Growful Pharmaceutical Co., Ltd.
Active
China
-
JiLin Yong Li Pharmaceutical Co., Ltd.
Active
China
-
Zhejiang Apeloa Kangyu Pharmaceutical Co., Ltd.
Active
China
Recommended Suppliers of Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
-
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of fine chemicals,pharmaceutical materials -
![China]()
CN
3 YRS
Business licensed Certified factoryManufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
Latest News on Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
- BMS Over $900 Million to Help Develop Potential 'Best-in-class' SHP2 Inhibitors
- AbbVie's blockbuster product for atopic dermatitis, Upadacitinib, has been approved for marketing in the EU and Japan
- Designing peptide inhibitors for possible COVID-19 treatments
- Chinese scientists discover the inhibitors of SARS-CoV-2
Learn More Other Chemicals
-
Piperazine, 1-(3-methylphenyl)-, hydrochloride (1:2)
13078-13-2
-
Piperazine, 1-(phenylmethyl)-4-tricyclo[3.3.1.13,7]dec-1-yl-, hydrochloride (1:2)
38916-93-7
-
Piperazine, 1-[2-[2-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:2)
94023-00-4
-
Piperazine, 1-(5-bromo-2-pyridinyl)-, hydrochloride (1:1) Formula
1187386-40-8
-
Piperazine, 1-(phenylmethyl)-4-[2-(3-piperidinyl)ethyl]-, hydrochloride (1:2) Formula
1220035-69-7
-
Piperazine, 1-(4-bromophenyl)-, hydrochloride (1:1) Formula
68104-62-1
-
Piperazine, 1-[3-(trifluoromethyl)phenyl]-, hydrochloride (1:1) Structure
16015-69-3
-
Piperazine, 1,4-bis(2-chloroethyl)-, hydrochloride (1:1) Structure
63980-44-9
-
What is Piperazine, 1-(4-methoxyphenyl)-, hydrochloride (1:1)
84145-43-7
-
What is Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-, hydrochloride (1:?)
18719-22-7
Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
SDSRequest for Quotation