Hyaluronoglucosaminidase
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Hyaluronoglucosaminidase
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CAS No:
37326-33-3
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Chemical Name:
Hyaluronoglucosaminidase
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Synonyms:
Hyaluronoglucosaminidase;Hyaluronoglucosidase;E.C. 3.2.1.35;Hyalosidase;Hyaluronate 4-glycanohydrolase;Hyaluronidase;Neopermease;E.C. 3.2.1.34;Hyalase;Chondroitinase;Chondroitinase I;Hydase;Hyase;9012-81-1;9079-81-6
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CAS No:
Description
Hyaluronidase (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is a naturally occurring enzyme that depolymerizes hyaluronic acid by cleavage of glycosidic bonds and has been used as a local anesthetic additive[1][2].
Characteristics
2.41
yellow-brown powder
1.5±0.1 g/cm3
598.6±50.0 °C at 760 mmHg
223.2±23.6 °C
1.642
soluble in water, practically insoluble in acetone and in anhydrous ethanol
−20°C
Hyaluronoglucosaminidase Use and Manufacturing
Using sheep testicles as raw materials, the acetic acid extract is preliminarily precipitated with ammonium sulfate, and after dialysis, it is again fractionated and precipitated with ammonium sulfate and ethanol, and the product is refined.
It is used for biochemical research and is commonly used clinically to promote the dissipation of local edema or hematoma after surgery and trauma, promote the infiltration of local anesthetics, reduce pain at the injection site, accelerate the absorption of subcutaneous and intramuscular injections, and can also be used for intestinal adhesions.
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