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HOE 140

HOE 140 structure

CAS No:
130308-48-4
Formula:
C59H89N19O13S
Chemical Name:
HOE 140
Synonyms:
RRP-(HYP)-G-(THI)-S-(D-TIC)-(OIC)-R;H-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH;H2N-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH;HOE 140;HOE 140 2ACOH 4H2O;D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG;D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG 2ACOH 4H2O;D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ
Categories:
Biochemical Engineering > Polypeptide

Description

ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.

Solid

HOE 140 Basic Attributes

Molecular Weight：

1304.52

Exact Mass：

1303.660767

ATC Code：

B06AC02|B - Blood and blood forming organs

Characteristics

PSA：

544.46000

XLogP3：

1.58520

Appearance：

white powder

Density：

1.60±0.1 g/cm3(Predicted)

Refractive Index：

1.742

Water Solubility：

5.70e-02 g/L

Storage Conditions：

−20°C

Safety Information

wgk germany：

Drug Information

Drug Indication：

Firazyr is indicated for symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults (with C1-esterase-inhibitor deficiency).|Treatment of ACE inhibitor-induced angioedema|Icatibant Accord is indicated for symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults, adolescents and children aged 2 years and older, with C1 esterase inhibitor deficiency.

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds and drugs that inhibit ligand binding or cellular signaling by BRADYKININ B2 RECEPTORS. (See all compounds classified as Bradykinin B2 Receptor Antagonists.)

MeSH Entry Terms：

D-Arg(Hyp(3)-Thi(5)-D-Tic(7)-Oic(8))BK

HOE 140 Use and Manufacturing

Uses

Antagonist (bradykinin).

Use Classification：

Human drugs -> Firazyr -> EMA Drug Category|Cardiac therapy -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans|Human drugs -> Icatibant Accord -> EMA Drug Category|Other hematological agents -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:1304.5
XLogP3:-6.4
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:30
Exact Mass:1303.66079514
Monoisotopic Mass:1303.66079514
Topological Polar Surface Area:552
Heavy Atom Count:92
Complexity:2720
Defined Atom Stereocenter Count:7
Undefined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of HOE 140

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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HOE 140

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