OMEGA-CONOTOXIN GVIA
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OMEGA-CONOTOXIN GVIA
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CAS No:
106375-28-4
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Formula:
C120H182N38O43S6
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Chemical Name:
OMEGA-CONOTOXIN GVIA
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Synonyms:
CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2;CKS(HYP)GSSCS(HYP)TSYNCCRSCN(HYP)TKRCY-NH2;H-CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2;H-CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2 (DISULFIDE BRIDGES: 1-16, 8-19, 15-26);OMEGA-CONOTOXIN GVIA, CONUS GEOGRAPHUS;OMEGA-CONOTOXIN GVIA ISOMER;OMEGA-CGTX GVIA;OMEGA-CONOTOXIN GVIA
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CAS No:
Description
Omega-conotoxin GVIA is a heterodetic cyclic polypeptide consisting of the linear sequence Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 with three disulfide bridges between cysteine residues 1-16, 8-19 and 15-26. Isolated from the venom of the fish-hunting snail Conus geographus. It has a role as a venom, a neurotoxin, a calcium channel blocker and a marine metabolite. It is a polypeptide, a heterodetic cyclic peptide, an organic disulfide and a peptidyl amide.|A neurotoxic peptide, which is a cleavage product (VIa) of the omega-Conotoxin precursor protein contained in venom from the marine snail, CONUS geographus. It is an antagonist of CALCIUM CHANNELS, N-TYPE.
Safety Information
III
6.1(b)
3172
3
GL2665050
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P284, P301+P310, P302+P352, P304+P340, P310, P311, P312, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)|Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept. (See all compounds classified as Neurotoxins.)
Conus geographus Toxin
Computed Properties
Molecular Weight:3037.4
XLogP3:-15.8
Hydrogen Bond Donor Count:49
Hydrogen Bond Acceptor Count:54
Rotatable Bond Count:39
Exact Mass:3036.1580785
Monoisotopic Mass:3035.1547236
Topological Polar Surface Area:1500
Heavy Atom Count:207
Complexity:6820
Defined Atom Stereocenter Count:31
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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