Eurycomanone
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Eurycomanone
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CAS No:
84633-29-4
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Formula:
C20H24O9
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Chemical Name:
Eurycomanone
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Synonyms:
Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12,14,15-pentahydroxy-,(1β,11β,12α,15β)-;2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran,picrasa-3,13(21)-diene-2,16-dione deriv.;(1β,11β,12α,15β)-11,20-Epoxy-1,11,12,14,15-pentahydroxypicrasa-3,13(21)-diene-2,16-dione;Eurycomanone;Pasakbumin A;NSC 339187
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CAS No:
Description
Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.
Characteristics
172.21000
-1.95660
1.63±0.1 g/cm3(Predicted)
273-285 °C @ Solvent: Methanol, Diethyl ether
Eurycomanone Use and Manufacturing
Eurycomanone is known as a cytotoxic compound found in Eurycoma Longifolia Jack.Previous studies had noted its cytotoxic effects against various cancer cell lines. More recent research demonstrated the ability of Eurycomanone to suppress the expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Eurycomanone was shown to also exerts the ability to induce apoptosis through the up-regulation of p53 in human cervical carcinoma cells.
Computed Properties
Molecular Weight:408.4
XLogP3:-2.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:9
Exact Mass:408.14203234
Monoisotopic Mass:408.14203234
Topological Polar Surface Area:154
Heavy Atom Count:29
Complexity:896
Undefined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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