Cytochalasin A
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Cytochalasin A
structure -
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CAS No:
14110-64-6
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Formula:
C29H35NO5
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Chemical Name:
Cytochalasin A
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Synonyms:
2H-Oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione,6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-,(3E,9R,11E,12aS,13S,15S,15aS,16S,18aS)-;2H-Oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione,16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-;24-Oxa[14]cytochalasa-6(12),13,21-triene-1,20,23-trione,7-hydroxy-16-methyl-10-phenyl-,(7S,13E,16R,21E)-;(3E,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione;5-Dehydrophomin;Phomin,5,5-didehydro-;Cytochalasin A;Dehydrophomin;5,5-Didehydrophomin;2H-Oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione,6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-,[9R-(3E,9R*,11E,12aS*,13S*,15S*,15aS*,16S*,18aS*)]-;NSC 174119;11032-94-3;11041-99-9
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CAS No:
Characteristics
92.70000
2.83
White Powder
1.20±0.1 g/cm3(Predicted)
185-187 °C
725.1±60.0 °C(Predicted)
392.3±32.9 °C
1.590
soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.ethanol: 20 mg/mL, clear, colorless
−20°C
Safety Information
I
6.1(a)
UN 1544 6.1/PG 2
3
26/27/28-63
28-36/37-45
T+,T
P260-P264-P280-P284-P302 + P350-P310
H300-H310-H330-H361
|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P262, P264, P270, P271, P280, P281, P284, P301+P310, P302+P350, P304+P340, P308+P313, P310, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Cytochalasin A Use and Manufacturing
Cytochalasin A is one of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalasins, cytochalasin A exhibits potent inhibition of actin filament function leading to cell death by apoptosis and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of the class display diverse selectivity. Specifically, cytochalasin A is one of the few cytochalasins active against HIV-1 protease.
Computed Properties
Molecular Weight:477.6
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:477.25152322
Monoisotopic Mass:477.25152322
Topological Polar Surface Area:92.7
Heavy Atom Count:35
Complexity:901
Defined Atom Stereocenter Count:7
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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