Taltirelin
-
Taltirelin
structure -
-
CAS No:
103300-74-9
-
Formula:
C17H23N7O5
-
Chemical Name:
Taltirelin
-
Synonyms:
L-Prolinamide,(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-;L-Prolinamide,N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-,(S)-;(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide;TA 0910;Taltirelin;Ceredist
- Categories:
-
CAS No:
Description
Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agon
Taltirelin is an oligopeptide comprising of (4S)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid, L-histidine and L-prolinamide joined in sequence by peptide linkages. It is a thyrotropin-releasing hormone (TRH) analog. Its tetrahydrate form is approved in Japan for the treatment of spinal muscular atrophy. It has a role as a nootropic agent, a neuroprotective agent and an analgesic.
Characteristics
171
-4.09
1.447±0.06 g/cm3(Predicted)
72-75 °C
1.612
Store at +4°C
25D -13.6° (c = 1 in water)
Drug Information
Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)
(1-methyl-4,5-dihydroorotyl)-histidyl-prolinamide
Taltirelin Use and Manufacturing
Analog of thyrotropin releasing hormone TRH, with pronounced CNS activity. Used in the treatment of spinocerebellar degeneration.
Computed Properties
Molecular Weight:405.4
XLogP3:-3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:405.17606686
Monoisotopic Mass:405.17606686
Topological Polar Surface Area:171
Heavy Atom Count:29
Complexity:714
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of Taltirelin
-
![China]()
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of N-Diethyl-m-toluamide,6-Methyluracil,Anisole,4-Dimethoxybenzoic acid,CS (lacrimator),Daucosterol,N,N-Formylmorpholine,Epichlorohydrin,Tetramethylguanidine,Dimethicone,3InquiryCAS No.: 103300-74-9Grade: Industrial Grade -
![Georgia]()
GE
1 YR
Business licensedDistributor Supplier of Ethanol,Retatrutide,SLES,Tirzepatide,GHK-CU,Semaglutide,Glutathione,Mots-CInquiryCAS No.: 103300-74-9Grade: Industrial GradeContent: 90% -
![China]()
CN
7 YRS
Business licensed Certified factoryManufactory Supplier of Cosmetic peptides,beauty raw materials,custom peptides,pharmaceutical intermediatesInquiryUnit Price: $20-25 /UNIT FOBCAS No.: 103300-74-9Grade: Chemical GradeContent: 98% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of Peptides,Chemicals,API,AdditivesInquiryCAS No.: 103300-74-9Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of cosmetic peptideInquiryUnit Price: $100 /MT FOBCAS No.: 103300-74-9Grade: Cosmetics GradeContent: 95%
Learn More Other Chemicals
-
ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE
15958-92-6
-
CLIP
53917-42-3
-
Trilysine
13184-14-0
-
Alanylasparagine Formula
31796-57-3
-
2-[[(2S)-3-phenyl-2-[[(2R)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]amino]acetic acid Formula
75539-79-6
-
L-Arginyl-L-phenylalanyl-L-alanine Formula
67368-27-8
-
BNP-45 (RAT) Structure
123337-89-3
-
2-[[2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]propanoic acid Structure
17123-30-7
-
What is 4-(3-BROMOBENZYL)MORPHOLINE
364793-82-8
-
What is Z-GLY-GLU-OH
3916-39-0