H-TYR-GLY-GLY-PHE-MET-OH
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H-TYR-GLY-GLY-PHE-MET-OH
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CAS No:
58569-55-4
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Formula:
C27H35N5O7S
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Chemical Name:
H-TYR-GLY-GLY-PHE-MET-OH
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Synonyms:
porcine,beta-endorphin1-5;[Met5]Enkephalin acetate salt hydrate;methionine enkephalin acetate;N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionine;(methionine5)enkephalin;[5-Methionin]Enkephalin,EnkephalinM;[Met5]Enkephalinhydrateacetatesalt;TYR-GLY-GLY-PHE-MET H2O
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CAS No:
Description
Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.
One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.
Characteristics
225
1.80830
white powder
1.324 g/cm3
174-177 °C
1052.9ºC at 760 mmHg
590.6ºC
1.608
−20°C
Drug Information
Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as Neurotransmitter Agents.)
5 Methionine Enkephalin
H-TYR-GLY-GLY-PHE-MET-OH Use and Manufacturing
Using L-tyrosine, glycine, L-phenylalanine, and L-methionine as raw materials, the side chains of amino acids with side chains in amino acids are protected with protective agents according to their characteristics. Condensation reaction is carried out in the presence of the mixture, and then the protective agent is removed for purification.
Used in biochemical research and neurobiological research.
Computed Properties
Molecular Weight:573.7
XLogP3:-2.1
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:16
Exact Mass:573.22571965
Monoisotopic Mass:573.22571965
Topological Polar Surface Area:225
Heavy Atom Count:40
Complexity:847
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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