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Home > Encyclopedia > Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)

Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)

Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) structure

Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) 

structure
  • CAS No:

    156311-83-0

  • Formula:

    C17H27N7OP.F6P

  • Chemical Name:

    Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)

  • Synonyms:

    Phosphorus(1+),[3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-,(T-4)-,hexafluorophosphate(1-) (1:1);Phosphonium,tri-1-pyrrolidinyl(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)-,hexafluorophosphate(1-);Phosphorus(1+),(3-hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinyl-,(T-4)-,hexafluorophosphate(1-);3H-1,2,3-Triazolo[4,5-b]pyridine,phosphonium deriv.;PyAOP;[(7-Azabenzotriazol-1-yl)oxy]tris(pyrrolidino)phosphonium hexafluorophosphate

  • Categories:

    Biochemical Engineering  >  Condensing Agent

Description

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is white to off-white crystalline powder

Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) Basic Attributes

521.38

521.16600

1533716-785-6

29339900

Characteristics

62.6

5.41600

White to off-white Powder or Crystalline Powder

163-168 °C(lit.)

Soluble in water.

-20°C

Safety Information

NONH for all modes of transport

3

36/37/38

26-36

TH3890000

Xi

P261-P305 + P351 + P338

H315-H319-H335

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 157 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) Use and Manufacturing

Used as a coupling reagent in solid phase peptide synthesis.It is preferred over HATU, because it does not side react at the N-terminus of the peptide.Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen.

Computed Properties

Molecular Weight:521.4
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:5
Exact Mass:521.16565148
Monoisotopic Mass:521.16565148
Topological Polar Surface Area:62.6
Heavy Atom Count:33
Complexity:502
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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