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N-Methyl-N-(trimethylsilyl)trifluoroacetamide

N-Methyl-N-(trimethylsilyl)trifluoroacetamide structure

CAS No:
24589-78-4
Formula:
C6H12F3NOSi
Chemical Name:
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Synonyms:
Acetamide,2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)-;2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide;N-Methyl-N-(trimethylsilyl)trifluoroacetamide;MSTFA;N-Methyl-N-trimethylsilyltrifluoracetamide;NSC 339701;N-Methyl-N(trimethylsilyl) trifluoroacetamide
Categories:
Chemical Reagents > Silane Reagent

Description

Clear colorless to light yellow liquid

N-methyl-N-(trimethylsilyl)trifluoroacetamide is an N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent. It is a monocarboxylic acid amide, a N-silyl compound and a trifluoroacetamide.

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Basic Attributes

Molecular Weight：

199.25

Exact Mass：

199.25

BRN：

1941550

EC Number：

246-331-6

NSC Number：

339701

DSSTox ID：

DTXSID5067003

HScode：

29319090

Characteristics

PSA：

20.3

XLogP3：

2.09

Appearance：

Clear colorless to light yellow Liquid

Density：

1.074 g/cm³

Melting Point：

98-100°C

Boiling Point：

131-132 °C

Flash Point：

77 °F

Refractive Index：

1.381

Water Solubility：

Solubility in water: reaction

Storage Conditions：

2-8°C

Vapor Pressure：

8.8 mm Hg ( 27 °C)

Vapor Density：

>1 (vs air)

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 1993 3/PG 3

wgk germany：

hazard class code：

10-36/37/38-61-50/53-51/53

safety instructions：

26-36-37/39-16-45-53-61

RTECS Number：

AC9800000

Marks：

Xi,F,T,N

Hazard note：

Flammable

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H226-H315-H319-H335

GHS Classification：

|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 56 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

MSTFA

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Use and Manufacturing

Uses

In the derivatization reagents used for gas chromatography, the derivatization of silane derivatization reagent with sample compound is carried out by substituting silyl groups for the active hydrogens of hydroxyl, carboxyl, mercapto, amino and imino groups. The product of the derivatization reaction is silicon ether or silicon ester. Almost all compounds containing these active hydrogens can derivatize with silylation reagents, and the order of their reactivity is: alcohol>phenol>carboxylic acid>amine>amide. Efficient silylation reagent, used to derive non-steroidal anti-inflammatory analgesics from active silylation reagent. Suitable for amino, carboxyl, indolalkylamine, serotonin and tryptamine derivatization.

Manufacturing Info：

Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)-: ACTIVE

Computed Properties

Molecular Weight:199.25
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:199.06402503
Monoisotopic Mass:199.06402503
Topological Polar Surface Area:20.3
Heavy Atom Count:12
Complexity:184
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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N-Methyl-N-(trimethylsilyl)trifluoroacetamide

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