Diisooctyl phthalate

390.56

390.277008

248-523-5

6A121LGB40

0876

DTXSID0027933

Nearly colorless, viscous liquid

52.6

3-4 (estimated)

Colourless liquid

0.984 g/cm³ @ Temp: 20 °C

-4 °C

370 °C

>230 °F

1.489

Solubility in water: none

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

1 mm Hg ( 200 °C)

Relative vapour density (air = 1): 13.5

Oral-Rat LD50: 22000mg/kg; Oral-Mouse LD50: 2769 mg/kg

Combustible in case of open flame, high temperature and strong oxidant; burning emits irritating smoke

Mild odor

Henry's Law constant = 3.14X10-5 atm-cu m/mol at 25 °C (est)

Phthalate esters are soluble to various extents in many common organic solvents and oils. /Phthalate esters/|/VAPOR PRESSURE IS/ 1.0 MM HG @ 200 °C|... Resistance to migration from polymers, low temperature flexibility ... compatibility with polar polymers and additives over a wide range of compositions. /Phthalate esters/|Phthalate esters would be expected to have UV maxima in the 230 nm and 270 nm regions. /Phthalate esters/|Hydroxyl radical reaction rate constant = 2.06X10-11 cu cm/molec-sec at 25 °C (est)

Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

DI-ISOOCTYL PHTHALATE reacts exothermically with acids to generate isooctyl alcohol and phthalic acid. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by interaction with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides. Can generate electrostatic charges. [Handling Chemicals Safely, 1980. p. 250].

393 °C

1

62-63-61-60

23-36/37-24/25-2-45-53

TI1300000

Xn,T

Completely packed, lightly placed; storeroom ventilated, away from open flames, high temperature, and stored separately from oxidants

P201, P202, P273, P281, P308+P313, P405, P501

H360

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Diisooctyl phthalate is an indirect food additive for use only as a component of adhesives.|Diisooctyl phthalate is classified as a plasticizer when migrating from food-packaging material (for foods of high water content only).

USEPA; Ambient Water Quality Criteria Doc: Phthalate Esters (1980) EPA 440/5-80-067|Nat'l Research Council Canada; Phthalate Esters in the Aquatic Environment (1980) NRCC No. 17583|USEPA; Health and Environmental Effects Profile for Phthalate Esters; (1980) ECAO-CIN-146|USEPA/ECAO; Atlas Document for: Phthalate Esters (1980)|For more Special Reports (Complete) data for DIISOOCTYL PHTHALATE (6 total), please visit the HSDB record page.

Special Hazards of Combustion Products: None (USCG, 1999)|Combustible.

|Danger|H360 (83.81%): May damage fertility or the unborn child [Danger Reproductive toxicity]|P201, P202, P273, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 106 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Not required (USCG, 1999)

Water or foam may cause frothing.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Collect leaking liquid in sealable metal containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Separated from strong oxidants.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

NO open flames.

Use ventilation.

Protective gloves.

Wear safety spectacles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diisooctyl phthalate is produced, as an intermediate or final product, by process units covered under this subpart.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Effluent from a municipal waste incinerator in West Germany contained diisooctyl phthalate at a concn of 11.23 ug/cu m(1) and effluent from a hazardous waste incinerator contained concns of 371.93-454.41 ng/cu m(2). Leachate from a pesticide plant contained diisooctyl phthalate at concns of 0.015-30 mg/l(3). Diisooctyl phthalate was found in waste water effluent from a petrochemical plant at concns of not detected, 70.5, and 26.9 ug/L in July 1996, Jan 1997, and March 1997, respectively and found at not detected and 40.5 ug/L in industrial landfill leachate in Dec 1996 and March 1997(4). Diisooctyl phthalate has been identified, not quantified, in emissions of textile floor coverings(5), stack emissions of coal-burning steam plants(6) and fly ash from a municipal waste incinerator(7). Diisooctyl phthalate was identified, not quantified, in leachate from a municipal landfill in Barcelona, Spain(8).

SEDIMENT: Diisooctyl phthalate was identified, not quantified, in surface sediment from a section of the Calcasieu River, LA that is impacted by heavy industrial activity(1).|SOIL: Diisooctyl phthalate was found in 17% of soil samples taken in 2000 from 12 sites in Taihu Lake, China at concns of 0.72 to 1.59 ppb(1). Soil near a pesticide plant contained diisooctyl phthalate at a concn of 1,100 ppb(2).

URBAN/SUBURBAN: Diisooctyl phthalate was identified, not quantified, in household dusts(1). A series of air concentration measurements made at three sites near Niagara Falls in September 1982 and January-February 1983 found the average concentration of diisooctyl phthalate in particulate matter was 4.7 and 2.3 ng/cu m, respectively and concentrations in the gas phase were 0.340 and 1.1 ng/cu m(2).

Diisooctyl phthalate was identified, not quantified, in household dusts(1).

moderately toxic

LD50 Mouse oral > 26000 mg/kg bw|LD50 Rat oral 22600 mg/kg bw|LD50 Rabbit oral 13000m g/kg bw

/AQUATIC SPECIES/ Chronic toxicity studies were performed with commercial phthalate esters and Daphnia magna (14 phthalates) and rainbow trout (Oncorhynchus mykiss) (6 phthalates). ...For the higher-molecular-weight phthalate esters - dihexyl phthalate (DHP), butyl 2-ethylhexyl phthalate (BOP), di-(n-hexyl, n-octyl, n-decyl) phthalate (610P), di-(2-ethylhexyl) phthalate (DEHP), diisooctyl phthalate (DIOP), diisononyl phthalate (DINP), di-(heptyl, nonyl, undecyl) phthalate (711P), diisodecyl phthalate (DIDP), diundecyl phthalate (DUP), and ditridecyl phthalate (DTDP)-the GM-MATC values ranged from 0.042 to 0.15 mg/L. Survival was equally sensitive and sometimes more sensitive than reproduction. The observed toxicity to daphnids with most of the higher-molecular-weight phthalate esters appeared to be due to surface entrapment or a mode of toxicity that is not due to exposure to dissolved aqueous-phase chemical. ...

Diisooctyl phthalate's production and use as a plasticizer(1) may lead to its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.6X10+4(SRC), determined from a water solubility of 0.09 mg/L(2) and a regression-derived equation(3), indicates that diisooctyl phthalate is expected to be immobile in soil(SRC). Volatilization of diisooctyl phthalate from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 3.1X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 5.5X10-6 mm Hg(2), and water solubility(2). However, adsorption to soil is expected to attenuate volatilization(SRC). Diisooctyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). Diisooctyl phthalate is expected to biodegrade in soils based upon screening studies conducted with microbial cultures isolated from sewage and sludge with degradation ranges from 75 to 99%(4-6).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.6X10+4(SRC), determined from a water solubility of 0.09 mg/L(2) and a regression-derived equation(3), indicates that diisooctyl phthalate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 3.1X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 5.5X10-6 mm Hg(2), and water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.5 and 25 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 4.3 years if adsorption is considered(4). According to a classification scheme(5), a measured BCF of 207 in Mosquito fish(6) suggests bioconcentration in aquatic organisms high(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(6). Hydrolysis is not expected to be an important process(SRC) based on estimated hydrolysis half-lives of 3.4 years and 130 days at pHs 7 and 8, respectively(7). Diisooctyl phthalate incubated for 28 days in fresh water/sediment degraded 2, <1-10, and 4% at 12, 22, and 28 °C, respectively(6).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diisooctyl phthalate, which has a vapor pressure of 5.5X10-6 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase diisooctyl phthalate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 19 hours(SRC), calculated from its rate constant of 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase diisooctyl phthalate may be removed from the air by wet or dry deposition(SRC). Diisooctyl phthalate does contain chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of diisooctyl phthalate with photochemically-produced hydroxyl radicals has been estimated as 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 19 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 6.4X10-2 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 3.4 years and 130 days at pH values of 7 and 8, respectively(2). Diisooctyl phthalate does contain chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

A measured BCF value of 207 was reported for Mosquito fish exposed to 6.4 mg/L of diisooctyl phthalate over an unspecified exposure period(1). According to a classification scheme(2), this BCF value suggests that bioconcentration in aquatic organisms is high, assuming the compound is not metabolized by the organism(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(3).

The Koc of diisooctyl phthalate is estimated as 1.6X10+4(SRC), using a water solubility of 0.09 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diisooctyl phthalate is expected to be immobile in soil.

The Henry's Law constant for diisooctyl phthalate is estimated as 3.1X10-5 atm-cu m/mole(SRC) derived from its vapor pressure, 5.5X10-6 mm Hg(1), and water solubility, 0.09 mg/L(1). This Henry's Law constant indicates that diisooctyl phthalate is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2.5 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 25 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 4.3 years if adsorption is considered(3). Diisooctyl phthalate's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Diisooctyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

GROUND WATER: Diisooctyl phthalate was found in test wells surrounding three waste lagoons in the Netherlands at concns up to 100 ppb(1). Diisooctyl phthalate was detected in groundwater near an agricultural plot of land at concns of 0.065-0.20 mg/L(2).|SURFACE WATER: Diisooctyl phthalate was identified, not quantified, in the Waal River in the Netherlands(1). Diisooctyl phthalate was found in 83% of surface water samples taken in 2000 from 12 sites in Taihu Lake, China at concns of 0.301 to 15.1 ppb(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 5416 workers (158 of these were female) were potentially exposed to diisooctyl phthalate in the US(1). Occupational exposure to diisooctyl phthalate may occur through inhalation and dermal contact with this compound at workplaces where diisooctyl phthalate is produced or used. Use data indicate that the general population may be exposed to diisooctyl phthalate via dermal contact with consumer products containing this compound(SRC).

In rats, dogs and miniature pigs, 50 mg/kg was administered 21-28 days before oral administration of single dose of same compound labeled with (14)C in carbonyl group. Approximately 1/2 of (14)C was excreted in rat urine and 1/2 in feces, while dogs showed 69-80% in feces, and pigs 65-86% in urine.

Butylglycolbutyl phthalate (BGBP) or diisoocytl phthalate (DIOP) was administered in diet to male Sprague-Dawley rats, beagle dogs and miniature pigs in dose of 50 mg/kg for 21-28 days before oral administration of single dose of same compound labeled with (14)C in carbonyl group. Diisoocytl phthalate was less readily metabolized than butylglycolbutyl phthalate by all species.|Strains of Mycobacterium and Nocardia isolated because of their ability to use di(2-ethylhexyl) phthalate (DEHP) as sole carbon source also grew on diethyl, diisooctyl, and butyl benzyl phthalates. As the two bacteria grew on di(2-ethylhexyl) phthalate, they excreted products that increased the solubility of di(2-ethylhexyl) phthalate and diisooctyl, dihexyl, and diisodecyl but not butyl benzyl or di-n-butyl phthalates. The solubilizer was produced by Mycobacterium sp. even when grown on a water-soluble substrate such as acetate. Addition of the solubilizer to culture media enhanced the degradation of di(2-ethylhexyl) phthalate and diisooctyl phthalate by Mycobacterium sp. and Nocardia sp. but not butyl benzyl phthalate. The extent of di(2-ethylhexyl) phthalate degradation by Mycobacterium sp. in media amended with the solubilizer was reduced and the initiation of degradation was delayed if the solubilizer was first treated with protease. The effect of protease was not a result of its toxicity to Mycobacterium or use of the enzyme preparation for growth of the organism. The results thus show that microbial products increase the solubility of certain phthalates and enhance their degradation.

Produces no ill effects at normal temperatures but may give off irritating vapor at high temperature. (USCG, 1999)

Leave contaminated area; wash skin with soap and water; flush eyes with water. (USCG, 1999)

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/OTHER TOXICITY INFORMATION/ An increase in toxic polyneuritis has been reported in workers exposed primarily to dibutyl phthalates. Lesser levels of exposure to dioctyl, diisooctyl, benzylbutyl phthalates, and tricresyl phosphate were also noted.

diisooctyl phthalate

ALL PHTHALATE PLASTICIZERS: 89% IN POLYVINYL CHLORIDE RESINS; 3% IN OTHER VINYL RESINS; 3% IN CELLULOSE ESTER PLASTICS; 3% IN SYNTHETIC ELASTOMERS & OTHER POLYMERS; 2% IN OTHER APPLICATIONS (1974)

Grade: Technical

Plastics product manufacturing|1,2-Benzenedicarboxylic acid, 1,2-diisooctyl ester: ACTIVE|Compatible with vinyl chloride resins and some cellulosic resins.|MOST OF THE ISO-OCTYL ALCOHOLS USED TO MAKE ... /DI-ISO-OCTYL PHTHALATE/ ARE MIXTURES OF ISOMERS.|AS A PENETRATION AGENT FOR FUNGICIDES|THE FUNGICIDAL ACTIVITY OF BENOMYL WAS INCREASED BY FORMULATION WITH ESTERS, ESPECIALLY PHTHALIC ACID ESTERS INCLUDING GENOMOLL 100 (ISOOCTYL PHTHALATE).