podocarpusflavone A
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podocarpusflavone A
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CAS No:
22136-74-9
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Formula:
C31H20O10
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Chemical Name:
podocarpusflavone A
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Synonyms:
podocarpusflavone A;2-(4-Methoxyphenyl)-8-[2-hydroxy-5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one;2-(4-Methoxyphenyl)-8-[6-hydroxy-3-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one;4',5,5'',7,7''-Pentahydroxy-4'''-methoxy-3',8''-biflavone;8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;Podocurpusflavone A;8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-
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CAS No:
Description
Podocarpusflavone A is a DNA topoisomerase I inhibitor, have moderated anti-proliferative activity induce cell apoptosis in MCF-7, is developing anti-tumor drugstarget: DNA topoisomerase IIn vitro: podocarpusflavone-A show significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 4.56-16.24 μg/mL) and induce cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. PF (40 ug/mL, 24 hr) significantly induced about 10 folds of cell deaths and growth arrest in S-phase tha
Computed Properties
Molecular Weight:552.5
XLogP3:5.4
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:4
Exact Mass:552.10564683
Monoisotopic Mass:552.10564683
Topological Polar Surface Area:163
Heavy Atom Count:41
Complexity:1060
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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