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Nimbin

Nimbin structure

CAS No:
5945-86-8
Formula:
C30H36O9
Chemical Name:
Nimbin
Synonyms:
2H-Cyclopenta[b]naphtho[2,3-d]furan-10-acetic acid,5-(acetyloxy)-2-(3-furanyl)-3,3a,4a,5,5a,6,9,9a,10,10a-decahydro-6-(methoxycarbonyl)-1,6,9a,10a-tetramethyl-9-oxo-,methyl ester,(2R,3aR,4aS,5R,5aR,6R,9aR,10S,10aR)-;2H-Cyclopenta[b]naphtho[2,3-d]furan-10-acetic acid,6α-carboxy-2α-(3-furyl)-3,3aα,4aβ,5,5aα,6,9,9a,10α,10a-decahydro-5α-hydroxy-1,6,9aβ,10aβ-tetramethyl-9-oxo-,dimethyl ester,acetate;Nimbin;18,24-Dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic acid,6-(acetyloxy)-7,15:21,23-diepoxy-4,8-dimethyl-1-oxo-,dimethyl ester,(4α,5α,6α,7α,15β,17α)-;2H-Cyclopenta[b]naphtho[2,3-d]furan-10-acetic acid,6β-carboxy-2α-(3-furyl)-3,3aβ,4aβ,5,5aα,6,9,9a,10,10a-decahydro-5α-hydroxy-1,6,9aβ,10aβ-tetramethyl-9-oxo-,dimethyl ester,acetate;2H-Cyclopenta[b]naphtho[2,3-d]furan-10-acetic acid,5-(acetyloxy)-2-(3-furanyl)-3,3a,4a,5,5a,6,9,9a,10,10a-decahydro-6-(methoxycarbonyl)-1,6,9a,10a-tetramethyl-9-oxo-,methyl ester,[2R-(2α,3aα,4aβ,5α,5aα,6α,9aβ,10β,10aβ)]-;22076-43-3;25990-69-6
Categories:
Natural Products > Terpenes

Description

Nimbin is a intermediate limonoid isolated from Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier[1][2][3].

Nimbin is a limonoid found in Azadirachta indica. It has a role as a plant metabolite and a pesticide. It is an acetate ester, a limonoid, a member of furans, a cyclic terpene ketone, an enone, a tetracyclic triterpenoid and a methyl ester.

Nimbin Basic Attributes

Molecular Weight：

540.6

Exact Mass：

540.60

EC Number：

611-830-3

UNII：

N4CTG7K9IU

DSSTox ID：

DTXSID80208168

HScode：

13021920

Characteristics

PSA：

118

XLogP3：

3.93

Density：

1.3±0.1 g/cm3

Melting Point：

205 °C

Boiling Point：

606.1±55.0 °C at 760 mmHg

Flash Point：

320.4±31.5 °C

Refractive Index：

1.567

Storage Conditions：

-20°C Freezer

Specific rotation：

D24 +170° (abs ethanol)

Drug Information

MeSH Entry Terms：

nimbin

Nimbin Use and Manufacturing

A new limonoid

Computed Properties

Molecular Weight:540.6
XLogP3:2.3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:540.23593272
Monoisotopic Mass:540.23593272
Topological Polar Surface Area:118
Heavy Atom Count:39
Complexity:1160
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes