 Home > Encyclopedia > (-)-Deoxypodophyllotoxin

(-)-Deoxypodophyllotoxin

(-)-Deoxypodophyllotoxin structure

CAS No:
19186-35-7
Formula:
C22H22O7
Chemical Name:
(-)-Deoxypodophyllotoxin
Synonyms:
Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-,(5R,5aR,8aR)-;Podophyllotoxin,deoxy-;Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-,[5R-(5α,5aβ,8aα)]-;(5R,5aR,8aR)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;Deoxypodophyllotoxin;Desoxypodophyllotoxin;Anthricin;Silicicolin;4-Deoxypodophyllotoxin;(-)-Deoxypodophyllotoxin;(-)-Anthricin;AS 2-3;(-)-Desoxypodophyllotoxin;518-30-9;1836-86-8;24150-31-0;75805-80-0
Categories:
Natural Products > Lignans

Description

ChEBI: A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted a position 5 by a 3,4,5-trimethoxyphenyl group.

Deoxypodophyllotoxin is a member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group. It has a role as a plant metabolite, an antineoplastic agent and an apoptosis inducer. It is a lignan, a furonaphthodioxole, a gamma-lactone and a member of methoxybenzenes.

(-)-Deoxypodophyllotoxin Basic Attributes

Molecular Weight：

398.40588

Exact Mass：

398.41

UNII：

45NR8XYU1L

NSC Number：

403148

DSSTox ID：

DTXSID30318504

Characteristics

PSA：

72.4

XLogP3：

2.44

Density：

1.304±0.06 g/cm3(Predicted)

Melting Point：

168 °C

Boiling Point：

564.5±50.0 °C(Predicted)

Flash Point：

247.0±30.2 °C

Refractive Index：

1.587

Drug Information

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect. (See all compounds classified as Immunotoxins.)

Metabolism/Metabolites：

Deoxypodophyllotoxin has known human metabolites that include 5-(4-Hydroxy-3,5-dimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one, 5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one, and 6,7-Dihydroxy-4-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydro-1H-benzo[f][2]benzofuran-3-one.

MeSH Entry Terms：

deoxypicropodophyllin

(-)-Deoxypodophyllotoxin Use and Manufacturing

4-Deoxypodophyllotoxin is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. It is well known for its antitumor, antiviral, and anti-inflammatory activities. 4-Deoxypodophyllotoxin was also shown to inhibit the passive cutaneous anaphylaxis reaction.

Computed Properties

Molecular Weight:398.4
XLogP3:3.1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:398.13655304
Monoisotopic Mass:398.13655304
Topological Polar Surface Area:72.4
Heavy Atom Count:29
Complexity:598
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (-)-Deoxypodophyllotoxin

Guangzhou Yaoguang Technology Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Custom Synthetic Chemicals,Biological Stains,Pharmaceutical Intermediates,Cosmetic Grade Chemicals,Enzyme,Nucleosides,Indicators,Speciality Chemicals,Biological Chemicals,Enzyme Substrates

Desoxypodophyllotoxin, CAS:19186-35-7

Unit Price: $20-22 /KG FOB

CAS No.: 19186-35-7

Grade: Reagent Grade

Content: 99%

Inquiry
Nanjing Paron Technology Co., Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of chemicals

Desoxypodophyllotoxin high quality

CAS No.: 19186-35-7

Content: 97%

Inquiry

Learn More Other Chemicals

Nudol

86630-46-8
(1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bS)-10-acetyloxy-1,2,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,5,6,6a,7,8,8a,10,11,12,14b-tetradecahydropicene-4a-carboxylic acid

35959-01-4
Maritimetin

576-02-3
Isoscoparin Formula

20013-23-4
2,3-Dihydro-2,5-dihydroxy-6,8-dimethoxy-2-methyl-4H-naphtho[2,3-b]pyran-4-one Formula

1856-95-7
2,6-Di-tert-butyl-α-(dimethylamino)-p-cresol Formula

88-27-7
Agatharesinol Structure

7288-11-1
Niranthin Structure

50656-77-4
What is Sequirin C

18194-29-1
What is Hedyotisol B

95839-45-5

Hot Searches: dinitrogen trioxide formula; limestone formula; thiophene; diclofenac sod ec 75 mg; ch2f2; aluminum phosphate formula

Guide of (-)-Deoxypodophyllotoxin

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

(-)-Deoxypodophyllotoxin

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.