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Hypophyllanthin

Hypophyllanthin structure

Hypophyllanthin 

structure
  • CAS No:

    33676-00-5

  • Formula:

    C24H30O7

  • Chemical Name:

    Hypophyllanthin

  • Synonyms:

    Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7S,8S,9R)-;Hypophyllanthin;Naphthalene,1α-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6-methoxy-2β,3α-bis(methoxymethyl)-7,8-(methylenedioxy)-;Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7α,8β,9α)-;Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7R,8R,9S)-rel-;(7S,8S,9R)-9-(3,4-Dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)naphtho[1,2-d]-1,3-dioxole;NSC 619044

  • Categories:

    Natural Products  >  Lignans

Description

Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2].

Hypophyllanthin Basic Attributes

430.49

430.49

DTXSID50187355

Characteristics

64.61000

3.77

1.158

129-130 °C @ Solvent: Ethanol

511.1±50.0 °C at 760 mmHg

200.8±30.0 °C

1.536

Safety Information

22

Xn

Drug Information

(7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydronaphtho(1,2-d)(1,3)dioxole

Computed Properties

Molecular Weight:430.5
XLogP3:3.6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:430.19915329
Monoisotopic Mass:430.19915329
Topological Polar Surface Area:64.6
Heavy Atom Count:31
Complexity:560
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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