5-AMINO-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

The preparation method is to put ethyl cyanoacetate, triethyl orthoformate, catalyst and acetic acid into the reaction kettle, heat, start refluxing to vaporize the produced ethanol, then continue to heat up to 130～155℃, react for 6 h, after the reaction is over , Distill off triethyl orthoformate under reduced pressure, send the residue to the pyrazolamide reactor, add ethanol, continue to cool to about 0°C, add methylhydrazine ethanol solution, heat up and reflux for 1 h, evaporate ethanol, add toluene, and cool , Crystallization, filtration and drying to obtain the finished product.

1-Methyl-5-aminopyrazole-4-carboxylic acid ethyl ester, also known as 1-methyl-4-ethoxycarbonyl-5-pyrazolamide, is an intermediate of the herbicide pyrasulfuron.

Molecular Weight:169.18
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:169.085126602
Monoisotopic Mass:169.085126602
Topological Polar Surface Area:81
Heavy Atom Count:12
Complexity:174
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes