4-Fluoro-2-iodo-1-nitrobenzene

To a solution of 5-fluoro-2-nitroaniline (70.0 g, 448 mmol) in HCl (350 mL, 37percent in water) at 0° C. was added sodium nitrite (32.2 g, 469 mmol, in 100 mL water) dropwise. The mixture was stirred for 1 h at which time, potassium iodide (82.0 g, 490 mmol, in 100 mL HSilak reaction tube equipped with a magnetic stirrer was added11.4 mg of copper iodide, 5.9 mg of 1, 10-phenanthroline, 37 mg of 2-nitro-5-fluorobenzoic acid, 36 mg of sodium iodide and 4 mL of dimethylsulfoxide.The reaction was heated at 160 ° C for 24 hours in the presence of oxygen.After the reaction was completed, distilled water was added to quench the reaction, Extraction with ethyl acetate 3 times, each time 10mL, The combined organic phases are concentrated, 31.5 mg of 2-nitro-5-fluoroiodobenzene was obtained, The yield is 59percent.

Molecular Weight:267.00
XLogP3:2.5
Hydrogen Bond Acceptor Count:3
Exact Mass:266.91925
Monoisotopic Mass:266.91925
Topological Polar Surface Area:45.8
Heavy Atom Count:11
Complexity:161
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes