Formetanate hydrochloride

257.72

257.09300

245-656-0

W0Y3OP0N2Z

379585

2757

DTXSID4032405

COLORLESS CRYSTALS|WHITE POWDER

29252900

53.9

2.81910

1.09g/cm3

201 °C (decomp)

1.5270 (estimate)

822,000 mg l -1 (25 °C)

0-6°C

1.6 x 10 -6 Pa (25 °C)

FAINT ODOR

DECOMP @ 200-202 °C

Hydrolyzed at pH less than 4 [EPA, 1998].

Carbamates

FORMETANATE HYDROCHLORIDE is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.

II

6.1(a)

2757

3

26/28-43-50/53

24-28-37/39-45-60-61

FC2514000

T+,N

Stable under normal storage conditions.

P260-P264-P273-P280-P284-P301 + P310

H300 + H330-H317-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

This material may burn but does not ignite readily. Container may explode in heat of fire. Hydrolyzed at pH less than 4 (EPA, 1998)

|Danger|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P320, P321, P330, P333+P313, P363, P391, P403+P233, P405, and P501|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P301+P310, P302+P352, P308+P313, P309+P311, P314, P321, P330, P333+P313, P363, P391, P405, and P501

(Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Wear self-contained breathing apparatus when fighting fire involving this material. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. (Non-Specific -- Carbamates Pesticide, Solid, n.o.s.) Extinguish fire using agent suitable for type of surrounding fire, as the material itself does not burn or burns with difficulty. Use water in flooding quantities as a fog. Use alcohol foam, carbon dioxide, or dry chemical. (EPA, 1998)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

(Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard areas and deny entry. Stay upwind and keep out of low areas. Do not touch spilled material or breathe the dusts, vapors, or fumes from burning materials. Do not handle broken packages without protective equipment. Wash away any material that may have contacted the body with soap and water. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Formetanate hydrochloride is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500/10,000 lbs.

LD50 Rat oral 21 mg/kg|LD50 Mouse oral 18 mg/kg|LD50 Beagle dog oral 19.1 mg/kg|LD50 Rat subcutaneous greater than 5600 mg/kg|LD50 Rabbit subcutaneous greater than 10200 mg/kg

Formetanate hydrochloride's use as an insecticide(1) will result in its release to the environment through various insecticidal applications(SRC).

TERRESTRIAL FATE: When dissolved in aqueous solutions, formetanate hydrochloride will have soil mobility ranging from medium to very high(3) based on estimated Koc values ranging from 3.2 to 212(1,2). In a thin-layer chromatography study of fungicide mobility in Hagerstown silty clay loam soils, formetanate hydrochloride had Rf factors of 0.75 and 0.79(4,5) that corresponds to a mobile soil mobility according to a classification scheme(6).|AQUATIC FATE: Formetanate hydrochloride is essentially nonvolatile from water based upon estimated Henry's Law constant of 2.3x10(-19) atm cu m/mol(1,2,SRC). Aqueous base-catalyzed hydrolysis (at 25 °C) is estimated as 1.8 l/mol sec which corresponds to half-lives of 4.5 days at pH of 8 and 45.3 days at pH of 7(4). Insufficient data are available to predict the relative importance or rate of biodegradation in aquatic conditions(SRC). Aquatic bioconcentration and adsorption are not expected to be important fate processes(SRC).|ATMOSPHERIC FATE: Based on an estimated vapor pressure of approximately 6.8X10-10 mm Hg at 25 °C(1), formetanate hydrochloride will exist primarily in the particulate phase in the ambient atmosphere(2). It will degrade in the vapor phase in the ambient atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 5 hrs(3). Physical removal of particulate formetanate hydrochloride from air is likely to occur through wet and dry deposition(SRC).

INCUBATION OF LABELED FORMETANATE WITH ALKALINE SOIL RESULTED IN 50% DECOMP IN LESS THAN 2 DAYS. MAJOR PRODUCTS WERE 3-FORMAMIDOPHENYL METHYLCARBAMATE, 3'-HYDROXYFORMANILIDE & M-AMINOPHENOL. IRRADIATION OF FORMETANATE WITH UV (254 NM) PRODUCED 3'-HYDROXYFORMANILIDE (THE MAIN PRODUCT), 3-FORMAMIDOPHENYL METHYLCARBAMATE AND M-[(DIMETHYLAMINO-METHYLENE) AMINO] PHENOL. N-DEMTHYLATION OF FORMETNANATE WAS OF MINOR IMPORTANCE PHOTOCHEMICALLY.|RIVER BOTTOM SOIL SAMPLES WERE MIXED WITH LABELED FORMETANATE & INCUBATED FOR UP TO 16 DAYS. AT THAT TIME, M-FORMAMINOPHENOL WAS METABOLITE PRESENT IN GREATEST (58.5%) AMT. ALSO PRESENT WERE ETHYLACETATE SOL CMPD M-FORMAMINOPHENYL-N-METHYLCARBAMATE (7.8%), DEMETHYLFORMETANATE (1.2%), M-AMINOPHENOL (19.0%), & M-(DIMETHYLAMINO-METHYLENEIMINO)PHENOL (1.9%). /FORMETANATE/|The rate constant for the vapor-phase reaction of formetanate hydrochloride with photochemically produced hydroxyl radicals has been estimated to be approximately 75.2X10-12 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 5 hours at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Aqueous base-catalyzed hydrolysis (at 25 °C) is estimated as 1.8 l/mol sec which corresponds to half-lives of 4.5 days at pH of 8 and 45.2 days at pH of 7(2,SRC). The free amine undergoes hydrolytic nucleophilic transformations in soil(3).

Based upon an experimental water solubility of 500,000 mg/l(1), the BCF of formetanate hydrochloride can be estimated to be approximately 0.38 from a regression-derived equation(2). According to this BCF value, bioconcentration in aquatic organisms is not expected to be an important fate process(SRC).

275.42 L/kg|Using a structure estimation method based on molecular connectivity indexes, the Koc for formetanate hydrochloride can be estimated to be about 212(1). The Koc for formetanate hydrochloride can be estimated to be about 3.2 based on an experimental water solubility of 500,000 mg/L(3) and a regression derived equation(2). According to a suggested classification scheme(4), these estimated Koc values suggest that formetanate hydrochloride soil mobility is medium to very high. In a thin-layer chromatography study of the fungicide in Hagerstown silty clay loam soils, formetanate hydrochloride had Rf factors of 0.75 and 0.79(5,6). According to a suggested classification scheme(7), these Rf factors suggest that formetanate hydrochloride would be mobile in soil.

The Henry's Law constant for formetanate hydrochloride can be estimated to be 2.3X10-19 atm-cu m/mole using a structure estimation method(1). This value of Henry's Law constant indicates that formetanate hydrochloride is essentially nonvolatile from water(2).

A study of pesticide residues in infant foods and adult foods eaten by infants/children (1985-1991), found formetanate hydrochloride in two out of 2464 samples of domestic apples at a maximum level of 0.21 ppm which is below the EPA tolerance limit of 3 ppm(1).

Pesticides, such as formetanate hydrochloride, can be absorbed into the body by three routes: dermal, inhalation, and ingestion(1). Formetanate hydrochloride has been detected in American foods(2); therefore the general population can be exposed through ingestion of contaminated foods(SRC).

5. 5= EXTREMELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-50 MG/KG, BETWEEN 7 DROPS & 1 TEASPOONFUL FOR 70 KG PERSON (150 LB). /FORMETANATE/

ORAL DOSE OF (14)C-FORMETANATE...WAS RAPIDLY ABSORBED & EXCRETED BY RAT; 85% IN URINE & 8% IN FECES. AFTER 72 HR, 2% OF THE (14)C WAS STILL RETAINED. /FORMETANATE/|Of a single dose of formetanate HCL to rats, 75% was excreted in the urine during the first 12 hr with peak concentrations observed at 6 hr. Within 24 hr after administration, 80% of the dose was eliminated in the urine and 6% in the feces ... . When 14-C-labeled formetanate HCL was orally administered to lactating goats at 1.4 mg/kg/day for 10 days, 80-90% of the dose was excreted in the urine within 24 hr of the last administration, and fecal excretion ranged from 1.3 to 6.6%. Two days after exposure began, radiolabel in the milk (as formetanate HCL) plateaued at 0.46 ppm. ...

RAT-LIVER FORMAMIDASE (ARYL FORMYLAMINE AMIDOHYDROLASE), NATURAL SUBSTRATE OF WHICH IS N-FORMYLKYNURENINE, IS ACTIVE IN HYDROLYSIS OF METABOLIC INTERMEDIATES OF.../ACARICIDE/...FORMETANATE. /FORMETANATE/|IN RATS TREATED WITH FORMETANATE...60-80% OF URINARY EXCRETORY PRODUCTS WERE WATER-SOL CONJUGATES. MAJOR AGLYCONE WAS 3-HYDROXYACETANILIDE...& OTHER AGLYCONES INCLUDED 3-HYDROXYFORMANILIDE, 3-FORMAMIDOPHENYL-N-METHYLCARBAMATE & M-[[(METHYLAMINO)METHYLENE]AMINO]PHENYL-N-METHYLCARBAMATE. /FORMETANATE/|About 84% of formetanate injected into houseflies was metabolized in 4 hours. The major metabolite was 3'-hydroxyformanilide. Microsomes from housefly abdomen plus NADH resulted in only 10% metabolism of formetanate. /Formetanate/

PHENYL N-METHYLCARBAMATES...EXERT THEIR INSECTICIDE ACTIVITY BY INHIBITING ENZYME CHOLINESTERASE.../& THEY DO NOT REQUIRE/ ACTIVATION BY METABOLISM BEFORE EXHIBITING THEIR ENZYME-INHIBITING PROPERTIES. /PHENYL N-METHYLCARBAMATES/|In 2-yr feeding trials dogs and rats receiving 200 mg/kg diet showed no significant abnormality.

Extremely toxic to humans. Not absorbed through contact with skin. Inhalation or ingestion may cause poisoning. Inhibits cholinesterase activity so effects are in relation to action on nervous system and can result in death. (EPA, 1998)

Note: Formetanate hydrochloride is a cholinesterase inhibitor. Signs and Symptoms of Formetanate Hydrochloride Exposure: Acute exposure to formetanate hydrochloride usually leads to a cholinergic crisis. Signs and symptoms may include increased salivation, profuse sweating, lacrimation (tearing), spontaneous defecation, and spontaneous urination. Pinpoint pupils, blurred vision, headache, tremor, muscle twitching, and loss of muscle coordination may occur. Malaise, mental confusion, convulsions, and coma may also be noted. Gastrointestinal effects include nausea, vomiting, diarrhea, and abdominal pain. Bradycardia (slow heart rate) occurs frequently. Pulmonary edema, dyspnea (shortness of breath), respiratory depression, or respiratory arrest may also occur. Emergency Life-Support Procedures: Acute exposure to formetanate hydrochloride exposure may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to formetanate hydrochloride. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100 % humidified oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to formetanate hydrochloride. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of formetanate hydrochloride is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of formetanate hydrochloride may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3- 1/2 oz) is recommended for adults. 6. Transport to a health care facility. (EPA, 1998)

1) ESTABLISH CLEAR AIRWAY & TISSUE OXYGENATION BY ASPIRATION OF SECRETIONS & IF NECESSARY, BY ASSISTED PULMONARY VENTILATION WITH OXYGEN. IMPROVE TISSUE OXYGENATION AS MUCH AS POSSIBLE BEFORE ADMINISTERING ATROPINE TO MINIMIZE THE RISK OF VENTRICULAR FIBRILLATION. /CARBAMATES, CHOLINESTERASE INHIBITORS/|2) ADMIN ATROPINE SULFATE IV, OR IM IF IV INJECTION IS NOT POSSIBLE... IN MODERATELY SEVERE POISONING: ADULT DOSAGE, INCLUDING CHILDREN OVER 12 YR: 0.4-2.0 MG REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED (TACHYCARDIA, FLUSHING, DRY MOUTH, MYDRIASIS). MAINTAIN ATROPINIZATION BY REPEATED DOSES FOR 2-12 HR, OR LONGER, DEPENDING ON SEVERITY OF POISONING... DOSAGE FOR CHILDREN UNDER 12 YEARS: 0.05 MG/KG BODY WT REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED. MAINTAIN ATROPINIZATION WITH REPEATED DOSAGE OF 0.02-0.05 MG/KG. SEVERELY POISONED INDIVIDUALS MAY EXHIBIT REMARKABLE TOLERANCE TO ATROPINE; TWICE THE DOSES SUGGESTED ABOVE MAY BE NEEDED... /CARBAMATES, CHOLINESTERASE INHIBITORS/|3. PRALIDOXIME (PROTOPAM-AYERST, 2-PAM) IS OF DOUBTFUL VALUE IN POISONINGS BY CARBAMATE INHIBITORS OF CHOLINESTERASE. ATROPINE ALONE IS ALMOST ALWAYS AN ADEQUATE ANTIDOTE. PRALIDOXIME IS PROBABLY CONTRAINDICATED IN POISONINGS BY CARBARYL, SPECIFICALLY. IF VICTIM OF CARBAMATE POISONING EXHIBITS SEVERE MUSCLE WEAKNESS &/OR RESPIRATORY DEPRESSION, OR IF POISONING INVOLVES A COMBINATION OF CARBAMATE & ORGANOPHOSPHATE, A DILUTE SOLUTION OF PRALIDOXIME (TOTAL DOSE IN 250 ML 5% GLUCOSE SOLN) MAY BE GIVEN CAUTIOUSLY IV. THE INFUSION SHOULD BE TERMINATED IF PATIENT'S CONDITION WORSENS. PRALIDOXIME DOSAGE: ADULTS, 1.0 G; FOR CHILDREN UNDER 12 YR, 20-50 MG/KG. 4. OBSERVE TREATED PATIENTS CLOSELY AT LEAST 24 HR TO INSURE THAT SYMPTOMS (POSSIBLY PULMONARY EDEMA) DO NOT RECUR AS ATROPINIZATION WEARS OFF. IN VERY SEVERE POISONINGS, METABOLIC DISPOSITION OF TOXICANT MAY REQUIRE SEVERAL HR OR DAYS DURING WHICH ATROPINIZATION MUST BE MAINTAINED. /CARBAMATES, CHOLINESTERASE INHIBITORS/|5. BATHE & SHAMPOO VICTIM WITH SOAP & WATER IF THERE IS ANY CHANCE THAT SKIN & HAIR ARE CONTAMINATED. 6. IF PESTICIDE HAS BEEN INGESTED IN QUANTITY SUFFICIENT TO CAUSE POISONING, EMPTY THE STOMACH & INTESTINE. A. IF VICTIM IS ALERT & RESPIRATION IS NOT DEPRESSED, GIVE SYRUP OF IPECAC, FOLLOWED BY 1-2 GLASSES OF WATER TO INDUCE VOMITING; ADULTS (INCLUDING CHILDREN OVER 12), 30 ML; CHILDREN (UNDER 12 YR), 15 ML. CAUTION: OBSERVE VICTIM CLOSELY AFTER ADMIN IPECAC, IF CONSCIOUSNESS LEVEL DECLINES, OR IF VOMITING HAS NOT OCCURRED IN 15 MIN, PROCEED IMMEDIATELY TO INTUBATE THE STOMACH. FOLLOWING EMESIS, HAVE VICTIM DRINK A SUSPENSION OF /PRC: 30 G ACTIVATED CHARCOAL IN 3-4 OZ OF WATER (CHILDREN), 100 G IN 8-10 OZ OF WATER (ADULTS)/...TO BIND TOXICANT REMAINING IN THE GI TRACT. /CARBAMATES, CHOLINESTERASE INHIBITORS/|For more Antidote and Emergency Treatment (Complete) data for FORMETANATE HYDROCHLORIDE (6 total), please visit the HSDB record page.

Symptomatology: 1. Nausea, vomiting, abdominal cramps, diarrhea & excessive salivation...sweating. 2. Lassitude & weakness. 3. Rhinorrhea and sensation of tightness in chest may occur with inhalation exposure. 4. Blurring or dimness of vision. Miosis...tearing, ciliary muscle spasm, loss of accommodation and ocular pain. None of these...signs...is dependable for diagnosis. Mydriasis may be seen... 5. Loss of muscle coordination, slurring of speech, fasciculation & twitching of muscles. 6. Difficulty in breathing, excessive secretions of saliva and of resp tract mucus, oronasal frothing, cyanosis, pulmonary rales & rhonchi, and hypertension. 7. ...jerky movements, incontinence, convulsions and coma. 8. Death...due to resp arrest of central origin, paralysis of resp muscles, intense bronchoconstriction or all three. /Carbaryl/

formetanate

75% AS AN INSECTICIDE & ACARICIDE ON DECIDUOUS FRUIT AND NUTS; 25% USED PRINCPLY ON ALFALFA (1974)|Formetanate hydrochloride usage in US agriculture for the following years in lbs AI/yr was: 1976 67,000, 1982 88,000, and 1989 500,000(1).

Water-soluble powder (formetanate +) chlordimeform

Methanimidamide, N,N-dimethyl-N'-[3-[[(methylamino)carbonyl]oxy]phenyl]-, hydrochloride (1:1): ACTIVE|INTRODUCED IN 1968 BY SCHERING, GERMANY; DEVELOPED IN USA & CANADA BY NOR-AM AGRICULTURAL PRODUCTS. US PATENT 3,336,186.|TECHNICAL MATERIAL 92% ACTIVE INGREDIENT. ... MITICIDE RECOMMENDED FOR USE ON APPLES & PEARS FOR CONTROL OF SPIDER MITES, RUST MITES, THRIPS & LYGUS SPECIES.|FORMETANATE IS ACARICIDE EFFECTIVE AGAINST MOTILE STAGES OF FRUIT TREE RED SPIDER MITES @ 420 G AI/HA (LV) OR 19 G AI/100 L (HV); AGAINST GLASSHOUSE RED SPIDER MITE ON ROSES, 1 SPRAY OF 25 G AI/100 L, ON CHRYSANTHEMUMS 2 SPRAYS @ 47.5 G/100 L. ... IT IS EFFECTIVE AS AN INSECTICIDE AGAINST SEVERAL PLANT BUGS, BEET FLY & THRIPS. /FORMETANATE/|...in France, 'Dicarzol 200', water soluble powder (250 g ai/kg) as hydrochloride; in North America as 'Carzol SP', water sol powder (920 g/kg) as hydrochloride; in some countries as a combined formulation with chlordimeform.|CARZOL SP--WATER SOL POWDER CONTAINING 95% TECHNICAL FORMETANATE HYDROCHLORIDE AND DICARZOL 200 @ 250 G AI/KG.

PRODUCT ANALYSIS IS BY TITRATION OF THE HYDROCHLORIDE WITH ALKALI. RESIDUES MAY BE DETERMINED BY SEPARATING THE AI BY TLC, FOLLOWED BY HYDROLYSIS TO 3-AMINOPHENOL WHICH IS EITHER DIAZOTIZED, COUPLED WITH N-(1-NAPHTHYL)ETHYLENEDIAMINE AND THE COLOR MEASURE AT 555 NM, OR BROMINATED AND ESTIMATED BY GLC WITH ELECTRON-CAPTURE DETECTION (NA JENNY & K KOSSMAN, ANAL METHODS PLANT GROWTH REGUL, 1973, 7, 279).|A strong cation exchange (SCX) liquid chromatographic method has been used for determination of formetanate hydrochloride residue in pome, citrus, and stone fruits. The limit of detection is 0.06 ppm.

Agrochemicals -> Acaricides, Insecticides