Cyclohexanamine, N-hydroxy-, hydrochloride (1:1)

General procedure: In a microwave vial the aldehyde derivative (15-23, 1 mmol), hydroxylaminehydrochloride (N-tert-butyl, N-benzyl or N-cyclohexyl, 1.5 mmol) and NaHCO3 (1.5 mmol) were added in 3-5mL oftetrahydrofuran at 90 C for 10 min with 10 s of pre-stirring.Dichloromethane (20 mL) was added and extracted with water(2 x 10 mL). The organic phases were combined, the solvent wasevaporated and the compound purified by silica gel flash chromatographyusing ethyl acetate:methanol (9:1) as eluting system. Thecontrol reaction was performed by TLC (silica gel, ethyl acetate).General procedure: In a microwave vial the aldehyde derivative (15-23, 1 mmol), hydroxylaminehydrochloride (N-tert-butyl, N-benzyl or N-cyclohexyl, 1.5 mmol) and NaHCO3 (1.5 mmol) were added in 3-5mL oftetrahydrofuran at 90 C for 10 min with 10 s of pre-stirring.Dichloromethane (20 mL) was added and extracted with water(2 x 10 mL). The organic phases were combined, the solvent wasevaporated and the compound purified by silica gel flash chromatographyusing ethyl acetate:methanol (9:1) as eluting system. Thecontrol reaction was performed by TLC (silica gel, ethyl acetate).General procedure: In a microwave vial the aldehyde derivative (15-23, 1 mmol), hydroxylaminehydrochloride (N-tert-butyl, N-benzyl or N-cyclohexyl, 1.5 mmol) and NaHCO3 (1.5 mmol) were added in 3-5mL oftetrahydrofuran at 90 C for 10 min with 10 s of pre-stirring.Dichloromethane (20 mL) was added and extracted with water(2 x 10 mL). The organic phases were combined, the solvent wasevaporated and the compound purified by silica gel flash chromatographyusing ethyl acetate:methanol (9:1) as eluting system. Thecontrol reaction was performed by TLC (silica gel, ethyl acetate).General procedure: In a microwave vial the aldehyde derivative (15-23, 1 mmol), hydroxylaminehydrochloride (N-tert-butyl, N-benzyl or N-cyclohexyl, 1.5 mmol) and NaHCO3 (1.5 mmol) were added in 3-5mL oftetrahydrofuran at 90 C for 10 min with 10 s of pre-stirring.Dichloromethane (20 mL) was added and extracted with water(2 x 10 mL). The organic phases were combined, the solvent wasevaporated and the compound purified by silica gel flash chromatographyusing ethyl acetate:methanol (9:1) as eluting system. Thecontrol reaction was performed by TLC (silica gel, ethyl acetate).General procedure: In a microwave vial the aldehyde derivative (15-23, 1 mmol), hydroxylaminehydrochloride (N-tert-butyl, N-benzyl or N-cyclohexyl, 1.5 mmol) and NaHCO3 (1.5 mmol) were added in 3-5mL oftetrahydrofuran at 90 C for 10 min with 10 s of pre-stirring.Dichloromethane (20 mL) was added and extracted with water(2 x 10 mL). The organic phases were combined, the solvent wasevaporated and the compound purified by silica gel flash chromatographyusing ethyl acetate:methanol (9:1) as eluting system. Thecontrol reaction was performed by TLC (silica gel, ethyl acetate).

Molecular Weight:151.63
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:151.0763918
Monoisotopic Mass:151.0763918
Topological Polar Surface Area:32.3
Heavy Atom Count:9
Complexity:59.5
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes