4-(Methylsulfonyl)phenylhydrazine hydrochloride

off-white to light yellow crystalline powder

100 mL of hydrochloric acid was placed in a 500 mL four-necked flask, The temperature inside the flask was cooled to -10 ° C. or lower in an ice water bath, While keeping the temperature in the flask not to exceed -10 ° C., 4- (methylsulfonyl) aniline 10.27 g(0.06 mol) were added and dissolved.After the fever ceased, While maintaining the temperature in the flask below -10 ° C., 4.47 g (0.065 mol) of sodium nitrite, In 30 g of distilled water was added dropwise over 1 hour.After completion of the dropwise addition, 67.7 g of tin chloride.dihydrate(0.30 mol) in 60 mL of hydrochloric acid, Was added dropwise over 1 hour while maintaining the temperature in the flask at -10 ° C. or lower, and the reaction proceeded.After completion of the reaction, the cake obtained by filtration was dried at 60 ° C. using a vacuum drier 12Dry for a while, 4- (Methylsulfonyl) phenylhydrazine hydrochloride(Intermediate G1) was obtained.The yield based on 4- (methylsulfonyl) aniline was 67.9 molpercent.

Molecular Weight:222.69
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:222.0229765
Monoisotopic Mass:222.0229765
Topological Polar Surface Area:80.6
Heavy Atom Count:13
Complexity:224
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes