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Gomisin A

pharmaceutical raw materials
Gomisin A structure

Gomisin A 

structure
  • CAS No:

    58546-54-6

  • Formula:

    C23H28O7

  • Chemical Name:

    Gomisin A

  • Synonyms:

    Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol,5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-,(6S,7S,13aR)-;Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol,5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-,stereoisomer;(6S,7S,13aR)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol;Gomisin A;Schisandrol B;Schizandrol B;Wuweizichun B;Wuweizi alcohol B;TJN 101;(+)-Gomisin A;Besigomsin;Schisantherinol B;61281-39-8

  • Categories:

    Natural Products  >  Lignans

Description

Schisandrol B is one of its major active constituents of traditional hepato-protective Chinese medicine, Schisandra sphenanthera.IC50 value:Target:in vitro: SolB pretreatment significantly attenuated the increases in alanine aminotransferase and aspartate aminotransferase activity, and prevented elevated hepatic malondialdehyde formation and the depletion of mitochondrial glutathione (GSH) in a dose-dependent manner. SolB also dramatically altered APAP metabolic activation by inhibiting


Besigomsin is a tannin.

Gomisin A Basic Attributes

416.46

416.46

DTXSID7048950

29329990

Characteristics

75.61000

3.60240

1.2±0.1 g/cm3

80-85 °C

579.7°C at 760 mmHg

304.4±30.1 °C

1.561

Safety Information

NONH for all modes of transport

24/25

P301 + P312 + P330

H302

Drug Information

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)

5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11-methylenedioxy-6-dibenzo(a,c)cyclooctenol

Computed Properties

Molecular Weight:416.5
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:416.18350323
Monoisotopic Mass:416.18350323
Topological Polar Surface Area:75.6
Heavy Atom Count:30
Complexity:588
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific pharmacological information is provided

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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