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Xylan sulfate

Xylan sulfate structure

CAS No:
37300-21-3
Formula:
H2O4S.xUnspecified
Chemical Name:
Xylan sulfate
Synonyms:
Xylan,hydrogen sulfate;Xylan sulfate;SR 25493;β-D-Xylan,(1→4)-,2,3-bis(hydrogen sulfate);Xylofuranan sulfate;Xylan polysulfate;104783-23-5;11096-31-4;39432-58-1;42613-02-5
Categories:
Chemical Reagents > Organic Reagents

Description

Solid

Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.|Pentosan Polysulfate is a semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. (NCI04)|A sulfated pentosyl polysaccharide with heparin-like properties.

Xylan sulfate Basic Attributes

Molecular Weight：

602.473

Exact Mass：

601.922

DSSTox ID：

DTXSID10190764

NCI Thesaurus Code：

C1755

Characteristics

PSA：

356

XLogP3：

-8

Water Solubility：

3.49e+00 g/L

Drug Information

Drug Indication：

For the relief of bladder pain or discomfort associated with interstitial cystitis.|FDA Label

Pharmacology：

Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects.

MeSH：

Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)

Absorption：

Slow

Biological Half-Life：

4.8 hours

Mechanism of Action：

Pentosan polysulfate is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.

MeSH Entry Terms：

BAY 946

Computed Properties

Molecular Weight:602.5
XLogP3:-5.6
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:21
Rotatable Bond Count:10
Exact Mass:601.92234227
Monoisotopic Mass:601.92234227
Topological Polar Surface Area:356
Heavy Atom Count:35
Complexity:1140
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Xylan sulfate, CAS:37300-21-3

Unit Price: $20-23 /KG FOB

CAS No.: 37300-21-3

Grade: Chemical Grade

Content: 99%

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