4-Bromo-2-hydroxybenzoic acid
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4-Bromo-2-hydroxybenzoic acid
structure -
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CAS No:
1666-28-0
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Formula:
C7H5BrO3
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Chemical Name:
4-Bromo-2-hydroxybenzoic acid
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Synonyms:
4-BROMOSALICYLIC ACID;4-BROMO-2-HYDROXYBENZOIC ACID;4-Bromo-2-Hydroxybenzoic Acid 2-Hydroxy-4-Bromobenzoic Acid;2-Hydroxy-4-bromobenzoicacid;4-Bromo-2-hydroxybenzoic acid 98%;4-Bromosalicyclic acid;4-Bromosalicylic acid, 5-Bromo-2-carboxyphenol;4-Bromosalicylic acid, >=98%
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CAS No:
4-Bromo-2-hydroxybenzoic acid Basic Attributes
217.02
215.942200
1312995-182-4
109120
DTXSID90296399
2918290000
Characteristics
57.5
3.2
1.861±0.06 g/cm3(Predicted)
164-165°C
330.2±32.0 °C(Predicted)
153.5±25.1 °C
1.655
6.78E-05mmHg at 25°C
Safety Information
Ⅲ
IRRITANT
2811
3
22-52/53
22-24/25-61
Xi,Xn
Irritant
P301 + P310
H301
|Danger|H301 (61.54%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 65 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-Bromo-2-hydroxybenzoic acid Use and Manufacturing
Reference Example 51 t-Butyl nitrite (5.10 g, 49.5 mmol) was added to a suspension of copper(II) bromide (8.80 g, 39.4 mmol) in CH[5-(4-Bromo-3-methoxy-phenyl)-3-methyl-2, 3-dihydro-[1, 3, 4]thiadiazol-2-yl]-cyclohexyl-amine First, take into 120g of phenol equipped with a stirrer, a thermometer and a dropping funnel 500mL three-necked flask, to which was added 60mL mass fraction of 69percent nitric acid, control the speed of 600r / min, a temperature of 15 , stir, wherein during the stirring, slowly added dropwise 40mL mass fraction of 75percent sulfuric acid, which was within 20min completion of dropping, the temperature until the addition is complete upgrade to 25 , and set the pressure to 1.2MPa, reaction 45min, to give 2-nitro phenol; and then placed in the above-obtained 2-nitro phenol reactor, to which was added 18mL mass fraction of 30percent hydrogen chloride, stir after adding 0.8g zinc powder at a temperature of 70 , under pressure of 1.3MPa conditions, and introducing hydrogen and sealed reactor, continuous reaction 1.5h, 2-amino-phenol; then take 18mL mass fraction of 37percent CHGeneral procedure: In a 10-mL round-bottom flask equipped with a magnetic stirring bar, 1 mM of the 2-nitrophenol was reacted with different amounts of the oxidant, acid, bromide source, and the vanadyl Schiff base complex in 4 mL of solvent. The content was stirred at room temperature.The progress of the reaction was monitored by GLC.Referential Example 38 [Referential Example 38] 2-Hydroxy-4-(4-pyridyl)benzoic acid
Computed Properties
Molecular Weight:217.02
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:215.94221
Monoisotopic Mass:215.94221
Topological Polar Surface Area:57.5
Heavy Atom Count:11
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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