Ginkgolide B
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Ginkgolide B
structure -
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CAS No:
15291-77-7
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Formula:
C20H24O10
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Chemical Name:
Ginkgolide B
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Synonyms:
9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione,3-(1,1-dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-,(1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-;Ginkgolide A,1-hydroxy-,(1β)-;5H-Dicyclopenta[b,c]furan-3,5a(6H)-diacetic acid,6-tert-butyl-3a-carboxyhexahydro-α5a,1,2,3,5,8-hexahydroxy-α3-methyl-,tri-γ-lactone;(1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione;Ginkgolide B;BN 52021;9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione,3-(1,1-dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-,[1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11β,11aR*)]-;BN 52051;Ginkgolides,ginkgolide B;Bilobalide B;99796-69-7;2304576-24-5
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CAS No:
Characteristics
148.82000
-1.36950
white crystal powder
1'+-.0.1 g/cm3(Predicted)
280°C(dec.)
762.4±60.0 °C(Predicted)
274.3±26.4 °C
1.651
Soluble in DMSO. Slightly soluble in water and ethanol
2-8°C
7.81E-27mmHg at 25°C
D24 -52.6° (c = 1 in ethanol)
Safety Information
NONH for all modes of transport
3
24/25
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)
BN 52021
Ginkgolide B Use and Manufacturing
Ginkgolide B is a diterpene lactone compound extracted from the root and dried leaves of Ginkgo biloba plant of the Ginkgo family. It is easily soluble in solvents such as ethyl acetate, methanol, ethanol, dimethyl sulfoxide, and contains Multiple reducing hydroxyl functional groups can directly scavenge and capture free radicals, inhibit the formation of harmful substances such as MDA, and have obvious anti-lipid peroxidation damage, thus delaying aging. At the same time, it has a specific antagonistic effect on platelet activating factor (PAF).
Computed Properties
Molecular Weight:424.4
XLogP3:-0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:1
Exact Mass:424.13694696
Monoisotopic Mass:424.13694696
Topological Polar Surface Area:149
Heavy Atom Count:30
Complexity:925
Undefined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
A terpene lactone component of Ginkgo biloba extract; acts as a platelet-activating factor (PAF) receptor antagonist with neuroprotective and anti-allergic effects.
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