1,4-Dichloro-2-methoxybenzene
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1,4-Dichloro-2-methoxybenzene
structure -
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CAS No:
1984-58-3
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Formula:
C7H6Cl2O
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Chemical Name:
1,4-Dichloro-2-methoxybenzene
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Synonyms:
Benzene,1,4-dichloro-2-methoxy-;Anisole,2,5-dichloro-;1,4-Dichloro-2-methoxybenzene;2,5-Dichloroanisole
- Categories:
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CAS No:
1,4-Dichloro-2-methoxybenzene Basic Attributes
177.03
177.03
2327401
217-852-6
8B3J0Y3CJ1
DTXSID8027452
29093090
Characteristics
9.2
3.3
Clear colorless to very slightly yellow Liquid
1.33
24 °C
128-132°C3,5mm
21°C
1.5615-1.5635
0.185mmHg at 25°C
Safety Information
1993
36/37/38-20/22
37/39-26-23
Xn,Xi
Irritant
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1,4-Dichloro-2-methoxybenzene Use and Manufacturing
1 , 2, 4-trichlorobenzene (TCB), NaOH (in the form of a 50 wt-percent solution in water) and methanol were charged into a pressure reactor. The molar ratio of TCB:NaOH:methanol was 1.0:2.4:10. Afterwards, the pressure reactor was sealed, heated to 190 °C under agitation and held at this temperature for 90 minutes. During the reaction, agitation was continued. The reactor was then cooled to room temperature using an ice-hbO bath. The reaction mixture was then transferred into a separation funnel and acidified with 10percent H2SO4 to a pH of below 1.5. The aqueous layer of the resulting two-layer mixture was then extracted three times with methylene chloride. The obtained yield of 2, 5-dichlorophenol was 64.6percent. The obtained regioselectivity (2, 5- dichlorophenol and 2, 5-dichlorophenol methyl ether / 2, 4-dichlorophenol and 2, 4-dichlorophenol methyl ether / 3, 4-dichlorophenol and 3, 4-dichlorophenol methyl ether) was 71 .9/15.5/12.6 (analysis using GC).
Intermediates
Pesticide, fertilizer, and other agricultural chemical manufacturing|Benzene, 1,4-dichloro-2-methoxy-: ACTIVE
Computed Properties
Molecular Weight:177.02
XLogP3:3.3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:175.9795702
Monoisotopic Mass:175.9795702
Topological Polar Surface Area:9.2
Heavy Atom Count:10
Complexity:108
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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