Lappaconitine hydrobromide
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Lappaconitine hydrobromide
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CAS No:
97792-45-5
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Formula:
C32H44N2O8.BrH
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Chemical Name:
Lappaconitine hydrobromide
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Synonyms:
Aconitane-4,8,9-triol,20-ethyl-1,14,16-trimethoxy-,4-[2-(acetylamino)benzoate],hydrobromide (1:1),(1α,14α,16β)-;Aconitane-4,8,9-triol,20-ethyl-1,14,16-trimethoxy-,4-[2-(acetylamino)benzoate],monohydrobromide,(1α,14α,16β)-;2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine,aconitane-4,8,9-triol deriv.;Lappaconitine hydrobromide;Allapinine;Allafort;97673-48-8;1103124-46-4;1262758-09-7;1435901-84-0;1581694-93-0
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CAS No:
Description
Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias.IC50 value:Target: A natural product for anti-cardiac arrhythmiasIn vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence [1]. In vivo: The effect of Lappaconitine hydrobromide on aconitine--induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels
Characteristics
126.79000
3.19060
white powder
223-226 °C (decomp)
740.8ºC at 760 mmHg
401.8ºC
2-8°C
Lappaconitine hydrobromide Use and Manufacturing
It is suitable for gastrointestinal ulcer, gastritis, hepatitis, cholecystitis, rheumatism, sciatica, toothache, postoperative pain, cancer pain and other symptoms.
Drug Function and Efficacy
It has strong analgesic effect, local anesthesia, cooling, antipyretic and anti-inflammatory and detumescent effects. Compared with pethidine, it has comparable analgesic effect, slightly slower onset and longer duration; the analgesic effect is 7 times that of the antipyretic analgesic aminopyrine. It is non-addictive, has no teratogenic effect in animal tests, and will not cause cumulative poisoning.
Registered Holders
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Gansu Lanyao Pharmaceutical Co., Ltd.
Active
China
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Guangxi Wuzhou Shennong Pharmaceutical Co., Ltd.
Active
China
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Shaanxi THE River Pharmaceutical. Co., Ltd.
Active
China
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