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4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione structure

CAS No:
64439-81-2
Formula:
C20H16N2O5
Chemical Name:
4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Synonyms:
1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-,(±)-;4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(±)-10-Hydroxycamptothecin;178949-21-8
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

(±)-10-Hydroxycamptothecin, an indole alkaloid isolated from Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Basic Attributes

Molecular Weight：

364.35

Exact Mass：

364.35

EC Number：

244-759-8

HScode：

2934999090

Characteristics

PSA：

100

XLogP3：

0.6

Density：

1.6±0.1 g/cm3

Melting Point：

230-237°C

Boiling Point：

820.7°C at 760 mmHg

Flash Point：

450.1±34.3 °C

Refractive Index：

1.777

Storage Conditions：

−20°C

Vapor Pressure：

1.67E-28mmHg at 25°C

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

36/37/38-25

safety instructions：

26-36-45

RTECS Number：

UQ0491000

Marks：

Xi,T

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Use and Manufacturing

Topoisomerase inhibitor

Drug Function and Efficacy

Hydroxycamptothecin is a cytotoxic anti-tumor drug. It is a cell cycle-specific drug that mainly acts in the S phase and selectively inhibits DNA topoisomerase I (TOPOI). TOPOI catalyzes the unwinding of supercoiled DNA for replication and transcription. This product inhibits the activity of TOPOI, thereby blocking DNA replication and transcription and interfering with the tumor cell proliferation cycle. Recent research literature suggests that hydroxycamptothecin may also induce differentiation and apoptosis of tumor cells.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Hydroxycamptothecin for injection
Ingredients	The chemical name is: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione.
Indication	Not yet clear.
Specifications	8 mg (calculated as hydroxycamptothecin)
Manufacturer	Yuanda Pharmaceutical Huangshi Feiyun Pharmaceutical Co., Ltd.

Hydroxycamptothecin for injection
Ingredients	The chemical name is: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione.
Indication	Not yet clear.
Specifications	5mg
Manufacturer	Sinopharm Group Luya(Shandong)Pharmaceutical Co., Ltd.

Hydroxycamptothecin for injection
Ingredients	The chemical name is: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione.
Indication	Not yet clear.
Specifications	4 mg (calculated as hydroxycamptothecin)
Manufacturer	Yuanda Pharmaceutical Huangshi Feiyun Pharmaceutical Co., Ltd.

Recommended Suppliers of 4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

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China Most Professional Factory Supply High Qulity 10-Hydroxycamptothecin CAS 19685-09-7 / 64439-81-2

CAS No.: 64439-81-2

Grade: Pharmaceutical Grade

Content: 99%

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Guide of 4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
Latest News
Learn More Other Chemicals

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

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