 Home > Encyclopedia > 4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione structure

CAS No:
64439-81-2
Formula:
C20H16N2O5
Chemical Name:
4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Synonyms:
1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-,(±)-;4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(±)-10-Hydroxycamptothecin;178949-21-8
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

(±)-10-Hydroxycamptothecin, an indole alkaloid isolated from Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Basic Attributes

Molecular Weight：

364.35

Exact Mass：

364.35

EC Number：

244-759-8

HScode：

2934999090

Characteristics

PSA：

100

XLogP3：

0.6

Density：

1.6±0.1 g/cm3

Melting Point：

230-237°C

Boiling Point：

820.7°C at 760 mmHg

Flash Point：

450.1±34.3 °C

Refractive Index：

1.777

Storage Conditions：

−20°C

Vapor Pressure：

1.67E-28mmHg at 25°C

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

36/37/38-25

safety instructions：

26-36-45

RTECS Number：

UQ0491000

Marks：

Xi,T

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Use and Manufacturing

Topoisomerase inhibitor

Drug Function and Efficacy

Hydroxycamptothecin is a cytotoxic anti-tumor drug. It is a cell cycle-specific drug that mainly acts in the S phase and selectively inhibits DNA topoisomerase I (TOPOI). TOPOI catalyzes the unwinding of supercoiled DNA for replication and transcription. This product inhibits the activity of TOPOI, thereby blocking DNA replication and transcription and interfering with the tumor cell proliferation cycle. Recent research literature suggests that hydroxycamptothecin may also induce differentiation and apoptosis of tumor cells.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Hydroxycamptothecin for injection
Ingredients	The chemical name is: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione.
Indication	Not yet clear.
Specifications	8 mg (calculated as hydroxycamptothecin)
Manufacturer	Yuanda Pharmaceutical Huangshi Feiyun Pharmaceutical Co., Ltd.

Hydroxycamptothecin for injection
Ingredients	The chemical name is: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione.
Indication	Not yet clear.
Specifications	5mg
Manufacturer	Sinopharm Group Luya(Shandong)Pharmaceutical Co., Ltd.

Hydroxycamptothecin for injection
Ingredients	The chemical name is: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione.
Indication	Not yet clear.
Specifications	4 mg (calculated as hydroxycamptothecin)
Manufacturer	Yuanda Pharmaceutical Huangshi Feiyun Pharmaceutical Co., Ltd.

Recommended Suppliers of 4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

LEADER BIOCHEMICAL GROUP Contact Supplier

CN
YRS

Business licensed Certified factory

Manufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances Chemicals

China Most Professional Factory Supply High Qulity 10-Hydroxycamptothecin CAS 19685-09-7 / 64439-81-2

CAS No.: 64439-81-2

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
DAHAI BIOCHEM LTD Contact Supplier

CN
YRS

Business licensed

Trader Supplier of HARD FAT

(s)-10-hydroxycamptothecin

Unit Price: nullnull /null null

CAS No.: 64439-81-2

Grade: Pharma Grade

Content: 99%

Inquiry

Learn More Other Chemicals

Imatinib mesylate

220127-57-1
4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile

236750-65-5
Temozolomide

85622-93-1
Imatinib Formula

152459-95-5
N-Desmethyl Imatinib Formula

404844-02-6
actinomycin D Formula

50-76-0
Epirubicin hydrochloride Structure

56390-09-1
Daunorubicin hydrochloride Structure

23541-50-6
What is Pirarubicin

72496-41-4
What is Bepotastine besilate

190786-44-8

Hot Searches: imide vs imine; food chemical suppliers; n-isopropylbenzylamine for sale; methylamine price per gallon; drospirenone-ee 3-0.02 mg tab; ammonium sulafte

Guide of 4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
Learn More Other Chemicals

4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.