Homoharringtonine | 26833-87-4, Homoharringtonine Formula

Description

Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

Omacetaxine is a semisynthetic cephataxine that acts as a protein translation inhibitor and is used to treated chronic myeloid leukemia that is resistant to tyrosine kinase receptor antagonists. Omacetaxine is associated with a low rate of serum enzyme elevation during therapy, but has not been linked to cases of clinically apparent liver injury with jaundice.

Homoharringtonine Basic Attributes

Molecular Weight：

545.62

Exact Mass：

545.62

DSSTox ID：

DTXSID0045678

Characteristics

PSA：

134.99000

XLogP3：

2.70

Appearance：

white to beige

Density：

1.3±0.1 g/cm3

Melting Point：

144-146 C

Boiling Point：

713.1±60.0 °C at 760 mmHg

Flash Point：

385.1±32.9 °C

Refractive Index：

1.605

Water Solubility：

DMSO: soluble20mg/mL, clear

Storage Conditions：

2-8°C

Vapor Pressure：

2.41E-21mmHg at 25°C

Safety Information

Packing level：

II

Hazard category：

6.1(a)

Transport codes：

UN 1544 6.1/PG 2

wgk germany：

3

hazard class code：

26/27/28-36/37/38-28

safety instructions：

36/37/39-45-27-26-36/37-28

RTECS Number：

FK0260000

Marks：

T+,Xi

Precautionary statement(s)：

P264-P301 + P310

Hazard Statements：

H300

GHS Classification：

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory.

Toxicity

Hepatotoxicity：

In controlled trials, serum aminotransferase elevations occurred in 2% to 6% patients treated with omacetaxine, but most elevations were mild and transient with only rare patients requiring dose modification or discontinuation for liver test abnormalities. Clinically apparent liver injury with jaundice was not reported in the preregistration trials of omacetaxine and is not mentioned in the product label. Since the approval and more wide scale use of omacetaxine, there have been no publications or descriptions of the hepatotoxicity with jaundice associated with its use. Thus, clinically apparent liver injury due to omacetaxine must be rare, if it occurs at all.

Drug Information

LiverTox Summary：

Omacetaxine is a semisynthetic cephataxine that acts as a protein translation inhibitor and is used to treated chronic myeloid leukemia that is resistant to tyrosine kinase receptor antagonists. Omacetaxine is associated with a low rate of serum enzyme elevation during therapy, but has not been linked to cases of clinically apparent liver injury with jaundice.

Drug Classes：

Antineoplastic Agents

Homoharringtonine Use and Manufacturing

Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of a-ketoes

Computed Properties

Molecular Weight:545.6
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:11
Exact Mass:545.26248182
Monoisotopic Mass:545.26248182
Topological Polar Surface Area:124
Heavy Atom Count:39
Complexity:968
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can inhibit the synthesis of eukaryotic cell proteins, disaggregate polyribosomes, and interfere with the function of protein ribosomes. It also has an inhibitory effect on the synthesis of intracellular DNA. It has the strongest killing effect on G1 and G2 phase cells, but has a smaller effect on S phase cells. It has no cross-resistance with cytarabine, mercaptopurine, etc.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Homoharringtonine Injection
Specifications	1ml: 1mg

Homoharringtonine Injection
Ingredients	Homoharringtonine: This product is an alkaloid extracted from Cephalotaxus fortunei Hook.f. or its congener plants of the Torreya grandis family.
Indication	(1) The dosage and course of treatment of this product should be adjusted when it is used in combination with other anticancer drugs or radiotherapy that may inhibit bone marrow function. (2) Anthracycline antibiotics have myocardial toxicity. Elderly patients and patients who have been repeatedly treated with anthracycline antibiotics such as doxorubicin or daunorubicin should use harringtonine with caution or not at all to avoid increased cardiotoxicity.
Specifications	1ml:1mg
Manufacturer	Cisen Pharmaceutical Co., Ltd.

Homoharringtonine Injection
Ingredients	Homoharringtonine: This product is an alkaloid extracted from Cephalotaxus fortunei Hook.f. or its congener plants of the Torreya grandis family.
Indication	(1) The dosage and course of treatment of this product should be adjusted when it is used in combination with other anticancer drugs or radiotherapy that may inhibit bone marrow function. (2) Anthracycline antibiotics have myocardial toxicity. Elderly patients and patients who have been repeatedly treated with anthracycline antibiotics such as doxorubicin or daunorubicin should use harringtonine with caution or not at all to avoid increased cardiotoxicity.
Specifications	2ml:2mg

See More Related Drugs

Registered Holders

MINSHENG GROUP SHAOXING PHARMACEUTICAL CO LTD

United States
Active
Minsheng Group Shaoxing Pharmaceutical Co., Ltd.

China
Active
Beijing Xiehe Pharmaceutical Co., Ltd.

China
Active

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CAS No.: 26833-87-4

Grade: Pharmaceutical Grade

Content: 99%

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