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Home > Encyclopedia > Meclizine dihydrochloride monohydrate

Meclizine dihydrochloride monohydrate

pharmaceutical raw materials
Meclizine dihydrochloride monohydrate structure

Meclizine dihydrochloride monohydrate 

structure
  • CAS No:

    31884-77-2

  • Formula:

    C25H27ClN2.2ClH.H2O

  • Chemical Name:

    Meclizine dihydrochloride monohydrate

  • Synonyms:

    Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-,hydrochloride,hydrate (1:2:1);Piperazine,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-,dihydrochloride,monohydrate;Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-,dihydrochloride,monohydrate;Meclizine dihydrochloride monohydrate

  • Categories:

    Active Pharmaceutical Ingredients  >  Antiallergic Drugs

Description

White Solid


Meclizine hydrochloride is a diarylmethane.|A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

Meclizine dihydrochloride monohydrate Basic Attributes

481.892

462.139618

1308068-626-2

2933499090

Characteristics

15.71000

6.97110

210-213°C

Insoluble in water.

-20°C Freezer

205.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

NONH for all modes of transport

P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, P501

H302

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

Agyrax

Meclizine dihydrochloride monohydrate Use and Manufacturing

Uses

For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:481.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:480.150197
Monoisotopic Mass:480.150197
Topological Polar Surface Area:7.5
Heavy Atom Count:31
Complexity:448
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes

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