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Ketotifen fumarate

Ketotifen fumarate structure

CAS No:
34580-14-8
Formula:
C19H19NOS.C4H4O4
Chemical Name:
Ketotifen fumarate
Synonyms:
10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one,4,9-dihydro-4-(1-methyl-4-piperidinylidene)-,(2E)-2-butenedioate (1:1);10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one,4,9-dihydro-4-(1-methyl-4-piperidinylidene)-,(E)-2-butenedioate (1:1);Ketotifen fumarate;Zaditen;Ketotifen hydrogen fumarate;Zaditor;Totifen;HC 20511;Allerkif;Zasten;HC 20511 fumarate;Alaway;126939-14-8
Categories:
Active Pharmaceutical Ingredients > Antiallergic Drugs

Description

Ketotifen (fumarate) is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.Target: Histamine Receptor Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt of fumaric acid,ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. In its oral form,

Ketotifen fumarate Basic Attributes

Molecular Weight：

425.5

Exact Mass：

425.129700

EC Number：

252-100-0

HScode：

2934999090

Characteristics

PSA：

123

XLogP3：

3.66410

Appearance：

White or off-white crystalline powder

Density：

0.968 g/mL at 25 °C(lit.)

Melting Point：

192 °C (decomp)

Boiling Point：

488.9ºC at 760 mmHg

Flash Point：

96-98°C/5mm

Refractive Index：

n20/D 1.522(lit.)

Water Solubility：

soluble in water (10 mg/ml), DMSO (100 mM), and methanol.

Storage Conditions：

Store at RT

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38-23/24/25

safety instructions：

36-45-36/37/39-26

RTECS Number：

DE8260000

Marks：

Xn,T

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Ketotifen fumarate Use and Manufacturing

Antiasthmatic; antiallergic.Antihistamines, antiasthmatic drugs, used to prevent and treat bronchitis and asthma

Drug Function and Efficacy

This product has both histamine H1 receptor antagonism and the effect of inhibiting the release of allergic reaction mediators. It not only has a strong anti-allergic effect, but also has a longer duration of efficacy. Therefore, it is more effective in preventing various bronchial asthma attacks and exogenous asthma than endogenous asthma.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ketotifen Fumarate Tablets
Ingredients	Ketotifen Fumarate
Indication	1. Concomitant use with various central nervous system depressants or alcohol can enhance the sedative effect of this product and should be avoided. 2. Do not use it with oral hypoglycemic drugs. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	1mg (calculated as C19H19NOS)
Manufacturer	Competent Investments Limited

Ketotifen Fumarate Tablets
Ingredients	Each tablet of this product contains the main ingredient ketotifen fumarate 1.38 mg (equivalent to ketotifen 1 mg).
Indication	1. Concomitant use with various central nervous system depressants or alcohol can enhance the sedative effect of this product and should be avoided. 2. Do not use it with oral hypoglycemic drugs. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	1mg (calculated as C19H19NOS)
Manufacturer	Sinopharm Zhonglian Pharmaceutical Co., Ltd.

Ketotifen Fumarate Tablets
Ingredients	Each tablet of this product contains the main ingredient ketotifen fumarate 1.38 mg (equivalent to ketotifen 1 mg).
Indication	1. Concomitant use with various central nervous system depressants or alcohol can enhance the sedative effect of this product and should be avoided. 2. Do not use it with oral hypoglycemic drugs. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	1mg (calculated as C19H19NOS)
Manufacturer	Wuhan Di'ao Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Zhejiang Shangtai Biopharmaceutical Co., Ltd.

China
Active
LABORATORI ALCHEMIA SRL

Italy
Active
OLON S.P.A.

Italy
Active

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Guide of Ketotifen fumarate

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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