Fosbretabulin disodium
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Fosbretabulin disodium
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CAS No:
168555-66-6
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Formula:
C18H21O8P.2Na
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Chemical Name:
Fosbretabulin disodium
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Synonyms:
Phenol,2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-,1-(dihydrogen phosphate),sodium salt (1:2);Phenol,2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-,dihydrogen phosphate,disodium salt,(Z)-;Phenol,2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-,dihydrogen phosphate,disodium salt;Combretastatin A4 disodium phosphate;Fosbretabulin disodium;Fosbretabulin disodium salt;CA 4DP;CA 4P;SML1131;229027-07-0
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CAS No:
Characteristics
119.15000
4.23930
white to beige
238-242 °C (decomp)
611.8°C at 760 mmHg
H2O: soluble5mg/mL, clear
Refrigerator
7.99E-16mmHg at 25°C
Fosbretabulin disodium Use and Manufacturing
Phosphorylated Combretastatin, a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage.A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.
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