 Home > Encyclopedia > Ulipristal acetate

Ulipristal acetate

Ulipristal acetate structure

CAS No:
126784-99-4
Formula:
C30H37NO4
Chemical Name:
Ulipristal acetate
Synonyms:
19-Norpregna-4,9-diene-3,20-dione,17-(acetyloxy)-11-[4-(dimethylamino)phenyl]-,(11β)-;(11β)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione;CDB 2914;RTI 3021-012;CBD(VA) 2914;VA 2914;17α-Acetoxy-11β-(4-dimethylaminophenyl)-19-norpregna-4,9-dien-3,20-dione;RU 44675;HRP 2000;Ulipristal acetate;17α-Acetoxy-11β-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione;EllaOne;Esmya;17-Acetoxy-11β-[(4-(N,N-dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione;17-Acetyloxy-11β-[(4-(N,N-dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione;17-Acetoxy-11β-[(4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione;136960-00-4;199015-61-7;1379515-47-5
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Pale Yellow SolidChEBI: A 20-oxo steroid obtained by acetylation of the 17-hydroxy group of (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-ol (ulipristal). A selective progesterone receptor modulator, which is empl yed as an emergency contraceptive.Ulipristal acetate (UPA) is a selective progesterone receptor modulator. Attributing to its higher efficacy and a similar rate of side effects compared to levonorgestrel emergency contraception, it is now recommended

Ulipristal acetate is a 20-oxo steroid obtained by acetylation of the 17-hydroxy group of (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-ol (ulipristal). A selective progesterone receptor modulator, which is employed as an emergency contraceptive. It has a role as a contraceptive drug, a progestin and a progesterone receptor modulator. It is a 3-oxo-Delta(4) steroid, a steroid ester, an acetate ester, a 20-oxo steroid and a tertiary amino compound. It derives from an estradiol.|Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. As a result, this agent may suppress the growth of uterine leiomyomatosis. Furthermore, by inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception

Ulipristal acetate Basic Attributes

Molecular Weight：

433.5824

Exact Mass：

475.62

EC Number：

1312995-182-4

UNII：

YF7V70N02B

DSSTox ID：

DTXSID30155294

NCI Thesaurus Code：

C91057

ATC Code：

G03XB02|G03AD02

Characteristics

PSA：

63.7

XLogP3：

4.48

Density：

1.19

Melting Point：

183-185 °C

Boiling Point：

640.1±55.0 °C(Predicted)

Flash Point：

340.9±31.5 °C

Refractive Index：

1.594

Vapor Pressure：

2.77E-16mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P280

Hazard Statements：

H361fd

GHS Classification：

|Danger|H302 (71.43%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P263, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P322, P330, P337+P313, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 7 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Ulipristal acetate is indicated for pre-operative treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age.Ulipristal acetate is indicated for intermittent treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age.|Ulipristal acetate is indicated for one treatment course of pre-operative treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age.Ulipristal acetate is indicated for intermittent treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age who are not eligible for surgery.|Emergency contraception within 120 hours (five days) of unprotected sexual intercourse or contraceptive failure.|Contraception|Leiomyoma of uterus

MeSH：

Contraceptive agents that act on the ENDOCRINE SYSTEM. (See all compounds classified as Contraceptive Agents, Hormonal.)|Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading. (See all compounds classified as Contraceptive Agents, Female.)

MeSH Entry Terms：

(11beta)-17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione

Ulipristal acetate Use and Manufacturing

Uses

Labelled Ulipristal

Use Classification：

Human drugs -> Esmya -> EMA Drug Category|Sex hormones and modulators of the genital system -> Human pharmacotherapeutic group|Human drugs -> Ulipristal Acetate Gedeon Richter -> EMA Drug Category|Human drugs -> ellaOne -> EMA Drug Category|Sex hormones and modulators of the genital system, Emergency contraceptives -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:475.6
XLogP3:3.5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:475.27225866
Monoisotopic Mass:475.27225866
Topological Polar Surface Area:63.7
Heavy Atom Count:35
Complexity:984
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Ulipristal acetate

Hangzhou Hyper Chemicals Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Best Price Ulipristal Acetate 126784-99-4 Spot delivery

CAS No.: 126784-99-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Xi'an Honest BioEngr Co.,Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10,Piracetam,Pregabalin,Ketoprofen,omeprazole,Fullerene C60,Melatonin,Nicotinamide riboside chloride,lactoferrin,Tylosin tartrate,Gentamycin Sulfate,Levamisole HCl,Praziquantel,Ivermectin,GA3,Pepsin,MT2,5 amino 1MQ,selank,semax

High-purity raw material Ulipristal AcetateCAS 126784-99-4 at competitive pricing

CAS No.: 126784-99-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
First Chems Co., LTD Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Titanium dioxide,npk,pvc,sles,labsa,mdi,tdi,Ethylene glycol,p-xylene,mtbe,styrene,Ethyl alcohol,Anthracite (coke),Citric acid,carbinol,toluene,Acetic acid,Dichloroethane,Phenol

Factory Direct Supply High Quality99% Purity Ulipristal Acetate 126784-99-4

CAS No.: 126784-99-4

Grade: Top Product

Content: 99%

Inquiry
Xian ZB Biotech Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Herb Extracts,Cosmetic raw materails,API

Ulipristal Acetate Powder CAS 126784-99-4 Ulipristal Acetate

CAS No.: 126784-99-4

Grade: Pharmaceutical Grade

Content: 99.00%

Inquiry
Beton Nutrition Corporation Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of olive leaf extract,ginger extract,ginseng extract,Black garlic extract,Echinacea purpurea extract,Horse Chestnut Extract,Pueraria extract,Andrographis Extract,citrus aurantium extract,quercetin,Rutin,chlorogenic acid,Curcumin,Apigenin

Ulipristal Acetate powder

CAS No.: 126784-99-4

Grade: Industrial Grade

Content: 98%

Inquiry