2-Chloro-5-hydroxy-4-pyridinecarboxaldehyde

A solution of 2-chloro- 5-(methoxymethoxy)pyridine-4-carbaldehyde ( 12 g, 59.52 mmol, 1.00 equiv) in tetrahydrofuran (80 mL) and 3M HCl (130 mL) was stirred for 1 h at 60°C. The reaction mixture was cooled to rt and the pH value of the solution was adjusted to 7 with 5percent aqueous sodium carbonate solution. The organic layer was collected and the aqueous layer was extracted with 400 mL of ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (1 :3) to give 6 g (64percent) of 2-chloro-5-hydroxypyridine-4-carbaldehyde as a light yellow solid. TLC: petroleum ether: ethyl acetate=2:1 , R

Molecular Weight:157.55
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:156.9930561
Monoisotopic Mass:156.9930561
Topological Polar Surface Area:50.2
Heavy Atom Count:10
Complexity:131
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes