4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE

B) to a 25 ml round-bottom flask is sequentially added in the compound B (1g, 5.29mmol), phosphorus oxychloride (4.82 ml, 52 . 9mmol) and phosphorus pentachloride (1.10g, 5 . 29mmol), then 106 °C reflux overnight, to evaporate the solvent, saturated sodium bicarbonate for adjusting to pH 7 - 8, ethyl acetate (40 ml * 2) extraction, the combined organic layer, sequentially water 80 ml, saturated salt water 80 ml extraction, anhydrous sodium sulfate drying. Residues rapidly through the silica gel column chromatography purification, using petroleum ether/ethyl acetate (V/V=8:1) elution, get compound C 0.96g, is a white solid, yield 80percent.4, 6-Dichloro-2-pyridin-2-yl-pyrimidine

Molecular Weight:226.06
XLogP3:2.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:224.9860526
Monoisotopic Mass:224.9860526
Topological Polar Surface Area:38.7
Heavy Atom Count:14
Complexity:181
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes