4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE
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4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE
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CAS No:
10235-65-1
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Formula:
C9H5Cl2N3
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Chemical Name:
4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE
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Synonyms:
Pyrimidine, 4,6-dichloro-2-(2-pyridinyl)-;4,6-Dichloro-2-(pyridin-2-yl);4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE Use and Manufacturing
B) to a 25 ml round-bottom flask is sequentially added in the compound B (1g, 5.29mmol), phosphorus oxychloride (4.82 ml, 52 . 9mmol) and phosphorus pentachloride (1.10g, 5 . 29mmol), then 106 °C reflux overnight, to evaporate the solvent, saturated sodium bicarbonate for adjusting to pH 7 - 8, ethyl acetate (40 ml * 2) extraction, the combined organic layer, sequentially water 80 ml, saturated salt water 80 ml extraction, anhydrous sodium sulfate drying. Residues rapidly through the silica gel column chromatography purification, using petroleum ether/ethyl acetate (V/V=8:1) elution, get compound C 0.96g, is a white solid, yield 80percent.4, 6-Dichloro-2-pyridin-2-yl-pyrimidine
Computed Properties
Molecular Weight:226.06
XLogP3:2.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:224.9860526
Monoisotopic Mass:224.9860526
Topological Polar Surface Area:38.7
Heavy Atom Count:14
Complexity:181
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE
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