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Home > Encyclopedia > N-Acetyl-3,5-diiodo-L-tyrosine

N-Acetyl-3,5-diiodo-L-tyrosine

N-Acetyl-3,5-diiodo-L-tyrosine structure

N-Acetyl-3,5-diiodo-L-tyrosine 

structure
  • CAS No:

    1027-28-7

  • Formula:

    C11H11I2NO4

  • Chemical Name:

    N-Acetyl-3,5-diiodo-L-tyrosine

  • Synonyms:

    L-Tyrosine,N-acetyl-3,5-diiodo-;Tyrosine,N-acetyl-3,5-diiodo-,L-;N-Acetyl-3,5-diiodo-L-tyrosine;3,5-Diiodo-N-acetyl-L-tyrosine;NSC 76100;N-Acetyl-3,5-diiodotyrosine;(2S)-2-Acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid;76733-10-3

  • Categories:

    Biochemical Engineering  >  Amino Acids and Derivatives

Description

White crystalline

N-Acetyl-3,5-diiodo-L-tyrosine Basic Attributes

475.02

475.02

213-837-3

76100

2924299090

Characteristics

86.6

2.1

White Powder

2.206±0.06 g/cm3(Predicted)

198-200 °C

532.9±50.0 °C(Predicted)

276.1±30.1 °C

1.693

−20°C

3.47E-12mmHg at 25°C

Safety Information

3

22-24/25

N-Acetyl-3,5-diiodo-L-tyrosine Use and Manufacturing

Methods of Manufacturing

Tyrosine is first iodinated with iodine and hydrochloric acid to produce 3, 5-diiodotyrosine, and then acylated with acetic anhydride to obtain the product.

Uses

N-Acetyl-3,5-diiodo-L-tyrosine has been used in the modeling system to study thyroid hormone biosynthesis.N-Acetyl-3,5-diiodo-L-tyrosine was also investigated for its ability to inhibit pepsin-catalyzed hydrolysis to determine the substrate binding region of the active center of the enzyme.

Computed Properties

Molecular Weight:475.02
XLogP3:2.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:474.87775
Monoisotopic Mass:474.87775
Topological Polar Surface Area:86.6
Heavy Atom Count:18
Complexity:314
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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