A-443654
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A-443654
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CAS No:
552325-16-3
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Formula:
C24H23N5O
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Chemical Name:
A-443654
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Synonyms:
A 443654;A-443654;A443654;(2s)-1-(1h-Indol-3-Yl)-3-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}propan-2-Amine;(S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine;(S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine;L20
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CAS No:
Description
A-443654 is a potent Akt1/2/3 inhbitor, with a Ki of 160 pM for Akt1.
(2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-2-propanamine is a member of indoles.
Computed Properties
Molecular Weight:397.5
XLogP3:3.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:397.19026037
Monoisotopic Mass:397.19026037
Topological Polar Surface Area:92.6
Heavy Atom Count:30
Complexity:562
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
