A 887826
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A 887826
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CAS No:
1266212-81-0
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Formula:
C26H29ClN4O3
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Chemical Name:
A 887826
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Synonyms:
5-(4-butoxy-3-chlorophenyl)-N-((2-morpholinopyridin-3-yl)methyl)nicotinamide;A 887826;A-887826;A887826;5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl]-3-pyridinecarboxamide;CHEMBL4303253;SCHEMBL18797632;DTXSID20677354
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CAS No:
Description
A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC50 of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo[1].
Characteristics
76.6
5.38230
white to beige
1.230±0.06 g/cm3(Predicted)
711.5±60.0 °C(Predicted)
DMSO: ≥5mg/mL
2-8°C
A 887826 Use and Manufacturing
A structurally novel, potent and voltage-dependent Nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats
Computed Properties
Molecular Weight:481.0
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:480.1928185
Monoisotopic Mass:480.1928185
Topological Polar Surface Area:76.6
Heavy Atom Count:34
Complexity:621
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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