(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
-
![(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/1e0f6595b20b46e4b356d9de3300d711.png "(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide")
(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
structure -
-
CAS No:
187947-37-1
-
Formula:
C30H42N2O2
-
Chemical Name:
(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
-
Synonyms:
5,8,11,14-Eicosatetraenamide,N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-,(5Z,8Z,11Z,14Z)-;5,8,11,14-Eicosatetraenamide,N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-,(all-Z)-;(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide;N-Arachidonoylserotonin;AA-5-HT
- Categories:
-
CAS No:
Description
N-arachidonoylserotonin is an N-acylserotonin obtained by formal condensation of the carboxy group of arachidonic acid with the primary amino group of serotonin. It has a role as a human metabolite, a signalling molecule, an antioxidant, an anti-inflammatory agent, an anticonvulsant, a capsaicin receptor antagonist and an EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor. It is a member of phenols and a N-acylserotonin. It derives from an arachidonic acid.
(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide Basic Attributes
462.67
462.67
(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide Use and Manufacturing
Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC 50 values are 5.6 μ M and 37-40 nM for FAAH and TRPV1 respectively). Inactive at cPLA 2 , CB 1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.
Fatty Acyls [FA] -> Fatty amides [FA08] -> N-acyl amines [FA0802]
Computed Properties
Molecular Weight:462.7
XLogP3:7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:17
Exact Mass:462.324628587
Monoisotopic Mass:462.324628587
Topological Polar Surface Area:65.1
Heavy Atom Count:34
Complexity:652
Defined Bond Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Learn More Other Chemicals
-
10-hydroxy-10-(3-octa-2,5-dienyloxiran-2-yl)deca-5,8-dienoic acid
103188-12-1
-
(5E,9E)-8-hydroxy-10-[3-[(2E,5E)-octa-2,5-dienyl]oxiran-2-yl]deca-5,9-dienoic acid
103188-13-2
-
(4-benzamidophenyl) (Z)-7-[(1R,2R,3R)-3-hydroxy-2-(2-hydroxy-3-phenoxypropoxy)-5-oxocyclopentyl]hept-4-enoate
106342-69-2
-
20-dimethyl-7-thiaprostaglandin E1 methyl ester Formula
111037-12-8
-
11-deoxyprostaglandin E1 4-hydroxyphenyl ester Formula
114495-95-3
-
16,18-ethano-20-ethyl-6-oxoprostaglandin E1 leucinamide Formula
115288-30-7
-
(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-20-oxo-6,8,10,14-eicosatetraenoic acid Structure
115609-68-2
-
EP 171 Structure
115825-93-9
-
What is 5,12,19-trihydroxyicosa-6,8,10,14-tetraenoic acid
117605-61-5
-
What is (E)-7-[5-chloro-2-[(E)-3-cyclohexyl-3-hydroxyprop-1-enyl]-3-hydroxycyclopentyl]hept-5-enoic acid
117708-11-9
(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
SDSRequest for Quotation