5-Acetyloxindole
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5-Acetyloxindole
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CAS No:
64483-69-8
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Formula:
C10H9NO2
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Chemical Name:
5-Acetyloxindole
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Synonyms:
5-ACETYLOXINDOLE;5-acetylindolin-2-one;5-acetyl-2-indolinone;1H-indol-5-yl acetate;5-Acetyl-1,3-dihydro-indol-2-one;2H-Indol-2-one,5-acetyl-1,3-dihydro-
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
5-Acetyloxindole Use and Manufacturing
5-Acetyl-2-oxindole 5-Acetyl-2-oxindole EXAMPLE I General procedure: A 50 mL round-bottom flask equipped with a reflux condenser and a magnetic stir bar was charged with indolin-2-one (10.0 mmol), ethanol(10 mL), acetone (7.3 mL, 0.1 mmol, 10.0 equiv), benzylamine(0.33 mL, 3.0 mmol, 0.3 equiv), and acetic acid (0.17 mL, 3.0 mmol, 0.3 equiv). Then, the reaction mixture was heated under reflux for 2 h. The precipitation was filtered off and washed with cold PE (10 mL). The obtained product was dried for 30 min and used without further purification.General procedure: To a stirred solution of oxindole 7 (1 equiv) in ethanol was added substituted triazole aldehyde 6 (1 equiv) and piperidine (0.01 equiv) and refluxed for 3 h. Completion of the reaction was checked by TLC (n-hexane/EtOAc; 3:7). The product was filtered and was purified using column chromatography (n-hexane/ethyl acetate) to give pure compound [E-8(a-b, d, f-m) and Z-8(a-c, e, i, k-m)] in good yields.EXAMPLE 43 A solution of EXAMPLE 40 A solution of
Computed Properties
Molecular Weight:175.18
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:175.063328530
Monoisotopic Mass:175.063328530
Topological Polar Surface Area:46.2
Heavy Atom Count:13
Complexity:249
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
