Ampalex
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Ampalex
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CAS No:
154235-83-3
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Formula:
C14H15N3O
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Chemical Name:
Ampalex
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Synonyms:
CX516; BDP 12; AMPAKINE CX516;BDP-12(Ampalex);ABT-224,PIPERIDINE, 1-(6-QUINOXALINYLCARBONYL)-;1-(QUINOXALIN-6-YLCARBONYL)PIPERIDINE;Ampalex;Piperidin-1-yl-quinoxalin-6-ylmethanone;Methanone, 1-piperidinyl-6-quinoxalinyl-;1-(6-Quinoxalinylcarbonyl)piperidine
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CAS No:
Ampalex Basic Attributes
241.29
241.29
200-256-5
Z5QU38B4V9
DTXSID70165574
white to light brown
2933990090
Characteristics
46.1
1.8
1.236±0.06 g/cm3(Predicted)
88-90°C
433.1±25.0 °C(Predicted)
215.8±23.2 °C
1.640
H2O: 5mg/mL, clear
Refrigerator
-0.14±0.30(Predicted)
2-8°C
Safety Information
NONH for all modes of transport
WGK 3
TM2785170
P264, P270, P301+P312, P330, P501
H302
Drug Information
Investigated for use/treatment in alzheimer's disease, memory loss, autism, neurologic disorders, dementia, schizophrenia and schizoaffective disorders, attention deficit/hyperactivity disorder (ADHD), and sleep disorders.
CX 516 is a benzylpiperidine AMPAkine, an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) modulator, that enhances the function of glutamate when it binds allosterically to the AMPA receptor channel complex. CX 516 slows receptor deactivation with a longer open time, slower excitatory postsynaptic potential (EPSP) decay and improvement of hippocampal long term potentiation (LTP).
1-(quinoxalin-6-ylcarbonyl)piperidine
Ampalex Use and Manufacturing
It is one of a series of AMPA modulators
Ampalex is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer''s disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4).