Acamprosate calcium
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Acamprosate calcium
structure -
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CAS No:
77337-73-6
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Formula:
C5H11NO4S.1/2Ca
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Chemical Name:
Acamprosate calcium
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Synonyms:
1-Propanesulfonic acid,3-(acetylamino)-,calcium salt (2:1);Aotal;Acamprosate calcium;Calcium N-acetylhomotaurinate;Campral EC;Sobriol;Alcomed;Ca-AOTA;Calcium bisacetyl homotaurine;Calcium acamprosate;Regtect
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CAS No:
Description
Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.IC50 value:Target: GABA receptorAcamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence.Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. In compari
Acamprosate calcium is an organic calcium salt. It contains an acamprosate(1-).|Structural analog of taurine that is used for the prevention of relapse in individuals with ALCOHOLISM.
Acamprosate calcium Basic Attributes
400.48
400.029
278-665-3
59375N1D0U
759186
DTXSID6047529
2924199090
Characteristics
189
1.05900
white, odorless or nearly odorless powder
270 °C
H2O: >5mg/mL
room temp
LD50 i.p. in male mice: 1.87 g/kg (Durlach, 1982)
Safety Information
NONH for all modes of transport
3
36/37/38
26-36/37/39-36
TZ6357000
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (95.24%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism. (See all compounds classified as Alcohol Deterrents.)
acamprosate
Acamprosate calcium Use and Manufacturing
glucocortcoid, antiinflammatory
Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:400.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:400.0286988
Monoisotopic Mass:400.0286988
Topological Polar Surface Area:189
Heavy Atom Count:23
Complexity:202
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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